MIR4661

Summary

MIR4661 (microRNA 4661, HGNC:41582) is a microRNA gene on chromosome 8q21.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616245 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41582
Approved symbol	MIR4661
Name	microRNA 4661
Location	8q21.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4661
Ensembl gene	ENSG00000266194
Ensembl biotype	miRNA
Entrez	100616245
RNAcentral	URS000075B7D3 — ncRNA, 75 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000582720

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000582720 — 1 exons

Exon	Start	End
ENSE00002688716	91205485	91205559

Expression profiles

Bgee: expression breadth broad, 16 present calls, max score 89.30.

Top tissues by expression

16 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
stomach	UBERON:0000945	89.30	gold quality
blood	UBERON:0000178	79.21	gold quality
right atrium auricular region	UBERON:0006631	66.12	gold quality
subcutaneous adipose tissue	UBERON:0002190	65.73	gold quality
lower esophagus muscularis layer	UBERON:0035833	64.87	gold quality
tibial nerve	UBERON:0001323	64.52	gold quality
right ovary	UBERON:0002118	62.43	gold quality
esophagus mucosa	UBERON:0002469	62.28	gold quality
right frontal lobe	UBERON:0002810	62.08	gold quality
omental fat pad	UBERON:0010414	61.93	gold quality
left lobe of thyroid gland	UBERON:0001120	61.64	gold quality
skin of abdomen	UBERON:0001416	60.77	gold quality
lung	UBERON:0002048	60.05	gold quality
thyroid gland	UBERON:0002046	59.70	gold quality
spleen	UBERON:0002106	56.01	gold quality
corpus callosum	UBERON:0002336	47.28	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.26

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Exosomal microRNA-4661-5p-based serum panel as a potential diagnostic biomarker for early-stage hepatocellular carcinoma. (PMID:32537885)
• A novel miR-466l-3p/FGF23 axis promotes osteogenic differentiation of human bone marrow mesenchymal stem cells. (PMID:38735373)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.