MIR4663

Summary

MIR4663 (microRNA 4663, HGNC:41623) is a microRNA gene on chromosome 8q24.13.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616260 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41623
Approved symbol	MIR4663
Name	microRNA 4663
Location	8q24.13
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4663
Ensembl gene	ENSG00000266324
Ensembl biotype	miRNA
Entrez	100616260
RNAcentral	URS000075B915 — miRNA, 76 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000582039

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000582039 — 1 exons

Exon	Start	End
ENSE00002722297	123215788	123215863

Expression profiles

Bgee: expression breadth broad, 46 present calls, max score 75.30.

Top tissues by expression

46 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
liver	UBERON:0002107	75.30	gold quality
blood	UBERON:0000178	75.29	gold quality
stomach	UBERON:0000945	72.96	gold quality
gastrocnemius	UBERON:0001388	71.76	gold quality
heart left ventricle	UBERON:0002084	70.69	gold quality
tibial artery	UBERON:0007610	70.63	gold quality
right atrium auricular region	UBERON:0006631	69.46	gold quality
body of stomach	UBERON:0001161	67.29	gold quality
lung	UBERON:0002048	66.87	gold quality
transverse colon	UBERON:0001157	66.79	gold quality
omental fat pad	UBERON:0010414	66.37	gold quality
left lobe of thyroid gland	UBERON:0001120	66.21	gold quality
substantia nigra	UBERON:0002038	65.79	gold quality
body of pancreas	UBERON:0001150	65.64	gold quality
right lobe of thyroid gland	UBERON:0001119	65.40	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	65.34	gold quality
skin of abdomen	UBERON:0001416	65.02	gold quality
thyroid gland	UBERON:0002046	64.70	gold quality
lower esophagus muscularis layer	UBERON:0035833	64.67	gold quality
body of uterus	UBERON:0009853	64.66	gold quality
right frontal lobe	UBERON:0002810	64.56	gold quality
esophagus mucosa	UBERON:0002469	64.30	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	64.01	gold quality
small intestine Peyer’s patch	UBERON:0003454	63.78	gold quality
nucleus accumbens	UBERON:0001882	63.41	gold quality
subcutaneous adipose tissue	UBERON:0002190	62.88	gold quality
frontal cortex	UBERON:0001870	62.73	gold quality
spleen	UBERON:0002106	62.65	gold quality
anterior cingulate cortex	UBERON:0009835	62.65	gold quality
putamen	UBERON:0001874	62.38	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.49

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.