MIR4664

Summary

MIR4664 (microRNA 4664, HGNC:41777) is a microRNA gene on chromosome 8q24.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616318 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41777
Approved symbol	MIR4664
Name	microRNA 4664
Location	8q24.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4664
Ensembl gene	ENSG00000265660
Ensembl biotype	miRNA
Entrez	100616318
RNAcentral	URS000075B408 — ncRNA, 71 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000583819

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000583819 — 1 exons

Exon	Start	End
ENSE00002692365	143733083	143733153

Expression profiles

Bgee: expression breadth ubiquitous, 110 present calls, max score 98.78.

Top tissues by expression

110 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right uterine tube	UBERON:0001302	98.78	gold quality
adrenal tissue	UBERON:0018303	93.61	gold quality
endometrium	UBERON:0001295	90.24	gold quality
right lobe of thyroid gland	UBERON:0001119	90.19	gold quality
left lobe of thyroid gland	UBERON:0001120	89.43	gold quality
thyroid gland	UBERON:0002046	89.04	gold quality
duodenum	UBERON:0002114	87.98	gold quality
sural nerve	UBERON:0015488	86.96	gold quality
metanephros cortex	UBERON:0010533	86.77	gold quality
body of pancreas	UBERON:0001150	85.29	gold quality
kidney	UBERON:0002113	85.14	gold quality
granulocyte	CL:0000094	85.09	gold quality
adult mammalian kidney	UBERON:0000082	84.34	gold quality
pancreas	UBERON:0001264	83.96	gold quality
placenta	UBERON:0001987	83.23	gold quality
vermiform appendix	UBERON:0001154	83.17	gold quality
esophagus mucosa	UBERON:0002469	82.91	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	82.88	gold quality
body of stomach	UBERON:0001161	81.64	gold quality
fallopian tube	UBERON:0003889	81.48	gold quality
liver	UBERON:0002107	81.39	gold quality
bone marrow	UBERON:0002371	81.27	gold quality
stomach	UBERON:0000945	81.15	gold quality
adrenal gland	UBERON:0002369	80.93	gold quality
saliva-secreting gland	UBERON:0001044	80.88	gold quality
minor salivary gland	UBERON:0001830	80.73	gold quality
left adrenal gland	UBERON:0001234	80.19	gold quality
left adrenal gland cortex	UBERON:0035825	79.87	gold quality
esophagus	UBERON:0001043	79.75	gold quality
right adrenal gland	UBERON:0001233	79.48	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.11

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Novel circular RNA hsa_circ_0036683 suppresses proliferation and migration by mediating the miR-4664-3p/CDK2AP2 axis in non-small cell lung cancer. (PMID:39113208)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.