MIR4665

Summary

MIR4665 (microRNA 4665, HGNC:41696) is a microRNA gene on chromosome 9p24.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616288 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41696
Approved symbol	MIR4665
Name	microRNA 4665
Location	9p24.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4665
Ensembl gene	ENSG00000263575
Ensembl biotype	miRNA
Entrez	100616288
RNAcentral	URS000075A915 — ncRNA, 79 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000581132

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000581132 — 1 exons

Exon	Start	End
ENSE00002707759	6007826	6007904

Expression profiles

Bgee: expression breadth broad, 40 present calls, max score 69.57.

Top tissues by expression

40 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	69.57	gold quality
body of stomach	UBERON:0001161	67.94	gold quality
body of pancreas	UBERON:0001150	65.33	gold quality
gastrocnemius	UBERON:0001388	65.30	gold quality
blood	UBERON:0000178	64.51	gold quality
heart left ventricle	UBERON:0002084	64.09	gold quality
caudate nucleus	UBERON:0001873	63.33	gold quality
left ovary	UBERON:0002119	63.31	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	62.86	gold quality
left coronary artery	UBERON:0001626	60.62	gold quality
spleen	UBERON:0002106	60.50	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	60.22	gold quality
lower esophagus muscularis layer	UBERON:0035833	58.45	gold quality
left adrenal gland cortex	UBERON:0035825	57.82	gold quality
skin of abdomen	UBERON:0001416	56.49	gold quality
tibial artery	UBERON:0007610	56.28	gold quality
transverse colon	UBERON:0001157	56.10	gold quality
subcutaneous adipose tissue	UBERON:0002190	55.88	gold quality
thoracic aorta	UBERON:0001515	54.61	gold quality
anterior cingulate cortex	UBERON:0009835	54.56	gold quality
putamen	UBERON:0001874	54.17	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	53.68	gold quality
ascending aorta	UBERON:0001496	53.37	gold quality
esophagus mucosa	UBERON:0002469	53.05	gold quality
muscle layer of sigmoid colon	UBERON:0035805	52.83	gold quality
omental fat pad	UBERON:0010414	52.68	gold quality
lung	UBERON:0002048	52.59	gold quality
skin of leg	UBERON:0001511	52.17	gold quality
thyroid gland	UBERON:0002046	51.61	gold quality
tibial nerve	UBERON:0001323	51.55	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• our results showed that miR-4665-3p was lowly expressed in gastric cancer tissues; MiRBase and Western blotting indicated that miR-4665-3p directly down-regulated the oncoprotein GSE1. (PMID:31692505)
• Results indicate that miR4665 was differentially upregulated in triplenegative breast cancer (TNBC) patients with recurrence allowing to distinguish them from those without recurrence. (PMID:31746410)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.