MIR4666A

Summary

MIR4666A (microRNA 4666a, HGNC:41750) is a microRNA gene on chromosome 1q42.13.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616308 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41750
Approved symbol	MIR4666A
Name	microRNA 4666a
Location	1q42.13
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4666
Ensembl gene	ENSG00000266174
Ensembl biotype	miRNA
Entrez	100616308
RNAcentral	URS000075BBE5 — ncRNA, 79 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000580160

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000580160 — 1 exons

Exon	Start	End
ENSE00002699205	228462074	228462152

Expression profiles

Bgee: expression breadth broad, 81 present calls, max score 89.24.

Top tissues by expression

81 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right hemisphere of cerebellum	UBERON:0014890	89.24	gold quality
cerebellar hemisphere	UBERON:0002245	89.14	gold quality
monocyte	CL:0000576	84.23	gold quality
vermiform appendix	UBERON:0001154	82.88	gold quality
muscle of leg	UBERON:0001383	80.87	gold quality
lymph node	UBERON:0000029	79.72	gold quality
kidney	UBERON:0002113	77.94	gold quality
endometrium	UBERON:0001295	75.48	gold quality
prefrontal cortex	UBERON:0000451	73.94	gold quality
islet of Langerhans	UBERON:0000006	73.20	gold quality
blood	UBERON:0000178	72.83	gold quality
adult mammalian kidney	UBERON:0000082	72.80	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	72.30	gold quality
right uterine tube	UBERON:0001302	72.23	gold quality
nucleus accumbens	UBERON:0001882	71.56	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	70.90	gold quality
heart left ventricle	UBERON:0002084	70.80	gold quality
Brodmann (1909) area 9	UBERON:0013540	70.70	gold quality
fallopian tube	UBERON:0003889	70.65	gold quality
frontal cortex	UBERON:0001870	70.59	gold quality
right frontal lobe	UBERON:0002810	70.50	gold quality
cerebral cortex	UBERON:0000956	70.11	gold quality
anterior cingulate cortex	UBERON:0009835	69.60	gold quality
gastrocnemius	UBERON:0001388	69.16	gold quality
putamen	UBERON:0001874	68.98	gold quality
hypothalamus	UBERON:0001898	68.89	gold quality
substantia nigra	UBERON:0002038	68.82	gold quality
right adrenal gland	UBERON:0001233	68.57	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	68.53	gold quality
caudate nucleus	UBERON:0001873	68.48	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.