MIR4667

Summary

MIR4667 (microRNA 4667, HGNC:41723) is a microRNA gene on chromosome 9p13.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616214 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41723
Approved symbol	MIR4667
Name	microRNA 4667
Location	9p13.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4667
Ensembl gene	ENSG00000263892
Ensembl biotype	miRNA
Entrez	100616214
RNAcentral	URS000075D106 — ncRNA, 66 nt, 10 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000578933

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000578933 — 1 exons

Exon	Start	End
ENSE00002727290	35608094	35608159

Expression profiles

Bgee: expression breadth broad, 78 present calls, max score 84.69.

Top tissues by expression

78 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
vermiform appendix	UBERON:0001154	84.69	gold quality
lymph node	UBERON:0000029	82.99	gold quality
Brodmann (1909) area 9	UBERON:0013540	80.89	gold quality
adrenal tissue	UBERON:0018303	77.85	gold quality
muscle of leg	UBERON:0001383	77.60	gold quality
right adrenal gland	UBERON:0001233	75.92	gold quality
gastrocnemius	UBERON:0001388	75.60	gold quality
blood	UBERON:0000178	74.67	gold quality
left adrenal gland cortex	UBERON:0035825	74.67	gold quality
fundus of stomach	UBERON:0001160	73.99	gold quality
adrenal gland	UBERON:0002369	73.02	gold quality
right coronary artery	UBERON:0001625	72.89	gold quality
right adrenal gland cortex	UBERON:0035827	72.70	gold quality
body of pancreas	UBERON:0001150	71.99	gold quality
left adrenal gland	UBERON:0001234	71.06	gold quality
tibial artery	UBERON:0007610	70.82	gold quality
right lobe of liver	UBERON:0001114	70.80	gold quality
popliteal artery	UBERON:0002250	70.75	gold quality
left coronary artery	UBERON:0001626	69.85	gold quality
body of stomach	UBERON:0001161	69.83	gold quality
urinary bladder	UBERON:0001255	69.58	gold quality
heart	UBERON:0000948	68.91	gold quality
right atrium auricular region	UBERON:0006631	68.61	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.52	gold quality
heart left ventricle	UBERON:0002084	68.34	gold quality
myometrium	UBERON:0001296	67.71	gold quality
colon	UBERON:0001155	67.58	gold quality
ascending aorta	UBERON:0001496	67.51	gold quality
thoracic aorta	UBERON:0001515	67.50	gold quality
thoracic mammary gland	UBERON:0005200	67.30	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.77

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• 3 novel miRNAs, MIR4458, MIR4667-5p, and MIR4668-5p, regulate autophagy-mediated elimination of B. pseudomallei by targeting ATG10 (PMID:26151773)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.