MIR4668

Summary

MIR4668 (microRNA 4668, HGNC:41545) is a microRNA gene on chromosome 9q31.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616114 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41545
Approved symbol	MIR4668
Name	microRNA 4668
Location	9q31.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4668
Ensembl gene	ENSG00000266315
Ensembl biotype	miRNA
Entrez	100616114
RNAcentral	URS000075E82F — miRNA, 70 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000582284

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000582284 — 1 exons

Exon	Start	End
ENSE00002719076	111932100	111932169

Expression profiles

Bgee: expression breadth broad, 96 present calls, max score 89.63.

Top tissues by expression

96 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skeletal muscle tissue	UBERON:0001134	89.63	gold quality
bone marrow	UBERON:0002371	86.92	gold quality
adrenal tissue	UBERON:0018303	86.55	gold quality
lower esophagus mucosa	UBERON:0035834	84.56	gold quality
vermiform appendix	UBERON:0001154	84.06	gold quality
duodenum	UBERON:0002114	83.96	gold quality
ectocervix	UBERON:0012249	82.63	gold quality
lymph node	UBERON:0000029	77.57	gold quality
endometrium	UBERON:0001295	77.43	gold quality
calcaneal tendon	UBERON:0003701	76.01	gold quality
blood	UBERON:0000178	75.30	gold quality
fundus of stomach	UBERON:0001160	74.80	gold quality
muscle of leg	UBERON:0001383	74.23	gold quality
stomach	UBERON:0000945	74.07	gold quality
gastrocnemius	UBERON:0001388	73.90	gold quality
right atrium auricular region	UBERON:0006631	73.88	gold quality
placenta	UBERON:0001987	73.84	gold quality
vagina	UBERON:0000996	73.53	gold quality
body of stomach	UBERON:0001161	73.24	gold quality
monocyte	CL:0000576	73.22	gold quality
islet of Langerhans	UBERON:0000006	72.91	gold quality
omental fat pad	UBERON:0010414	72.85	gold quality
heart	UBERON:0000948	72.81	gold quality
endocervix	UBERON:0000458	72.68	gold quality
skin of abdomen	UBERON:0001416	72.19	gold quality
heart left ventricle	UBERON:0002084	72.00	gold quality
esophagus mucosa	UBERON:0002469	71.89	gold quality
kidney	UBERON:0002113	71.76	gold quality
zone of skin	UBERON:0000014	71.44	gold quality
adipose tissue	UBERON:0001013	71.44	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.21

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• 3 novel miRNAs, MIR4458, MIR4667-5p, and MIR4668-5p, regulate autophagy-mediated elimination of B. pseudomallei by targeting ATG10 (PMID:26151773)
• Findings indicate that the effect of ultraconserved RNA uc.372 on abnormal lipid accumulation is subjected to regulation of miR-195/miR-4668 in the liver of non-alcoholic fatty liver disease (NAFLD) patients. (PMID:29426937)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.