MIR4669

Summary

MIR4669 (microRNA 4669, HGNC:41558) is a microRNA gene on chromosome 9q34.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616236 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41558
Approved symbol	MIR4669
Name	microRNA 4669
Location	9q34.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4669
Ensembl gene	ENSG00000263897
Ensembl biotype	miRNA
Entrez	100616236
RNAcentral	URS000075B83A — ncRNA, 62 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000585099

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000585099 — 1 exons

Exon	Start	End
ENSE00002702380	134379411	134379472

Expression profiles

Bgee: expression breadth tissue_specific, 9 present calls, max score 74.65.

Top tissues by expression

9 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
gastrocnemius	UBERON:0001388	74.65	gold quality
transverse colon	UBERON:0001157	72.27	gold quality
esophagus mucosa	UBERON:0002469	66.08	gold quality
skin of abdomen	UBERON:0001416	66.04	gold quality
tibial artery	UBERON:0007610	65.99	gold quality
liver	UBERON:0002107	65.61	silver quality
omental fat pad	UBERON:0010414	65.04	gold quality
blood	UBERON:0000178	62.96	gold quality
endocervix	UBERON:0000458	61.52	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.38

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Mir-4669 rs35196866 polymorphism is associated with Ischemic Stroke. (PMID:31781304)
• Overexpression of miR-4669 Enhances Tumor Aggressiveness and Generates an Immunosuppressive Tumor Microenvironment in Hepatocellular Carcinoma: Its Clinical Value as a Predictive Biomarker. (PMID:37175615)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.