MIR4670

Summary

MIR4670 (microRNA 4670, HGNC:41862) is a microRNA gene on chromosome 9q22.31.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616351 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41862
Approved symbol	MIR4670
Name	microRNA 4670
Location	9q22.31
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4670
Ensembl gene	ENSG00000264158
Ensembl biotype	miRNA
Entrez	100616351
RNAcentral	URS000075B566 — ncRNA, 75 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000583240

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000583240 — 1 exons

Exon	Start	End
ENSE00002704208	92527984	92528058

Expression profiles

Bgee: expression breadth broad, 33 present calls, max score 86.13.

Top tissues by expression

33 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	86.13	gold quality
calcaneal tendon	UBERON:0003701	83.64	gold quality
blood	UBERON:0000178	77.55	gold quality
lung	UBERON:0002048	76.16	gold quality
kidney	UBERON:0002113	74.39	gold quality
stomach	UBERON:0000945	72.18	gold quality
myometrium	UBERON:0001296	71.50	gold quality
body of stomach	UBERON:0001161	70.82	gold quality
intestine	UBERON:0000160	70.42	gold quality
monocyte	CL:0000576	70.37	gold quality
muscle layer of sigmoid colon	UBERON:0035805	68.01	gold quality
body of pancreas	UBERON:0001150	67.82	gold quality
liver	UBERON:0002107	67.54	gold quality
left adrenal gland cortex	UBERON:0035825	66.29	gold quality
tibial nerve	UBERON:0001323	66.09	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	65.77	gold quality
omental fat pad	UBERON:0010414	65.68	gold quality
corpus callosum	UBERON:0002336	64.28	gold quality
skin of leg	UBERON:0001511	63.38	gold quality
right hemisphere of cerebellum	UBERON:0014890	62.78	gold quality
lower esophagus muscularis layer	UBERON:0035833	62.48	gold quality
esophagus mucosa	UBERON:0002469	61.97	gold quality
left ovary	UBERON:0002119	61.26	gold quality
thyroid gland	UBERON:0002046	60.37	gold quality
cerebellar hemisphere	UBERON:0002245	60.27	gold quality
minor salivary gland	UBERON:0001830	60.17	gold quality
colon	UBERON:0001155	59.94	gold quality
skin of abdomen	UBERON:0001416	59.34	gold quality
small intestine Peyer’s patch	UBERON:0003454	59.22	gold quality
spleen	UBERON:0002106	58.56	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.82

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.