MIR4671

Summary

MIR4671 (microRNA 4671, HGNC:41598) is a microRNA gene on chromosome 1q42.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616380 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41598
Approved symbol	MIR4671
Name	microRNA 4671
Location	1q42.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4671
Ensembl gene	ENSG00000264377
Ensembl biotype	miRNA
Entrez	100616380
RNAcentral	URS000075DC4C — ncRNA, 73 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000583284

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000583284 — 1 exons

Exon	Start	End
ENSE00002708047	234306467	234306539

Expression profiles

Bgee: expression breadth broad, 54 present calls, max score 74.99.

Top tissues by expression

54 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	74.99	gold quality
blood	UBERON:0000178	74.51	gold quality
islet of Langerhans	UBERON:0000006	72.13	gold quality
endometrium	UBERON:0001295	71.08	gold quality
left adrenal gland	UBERON:0001234	70.09	gold quality
body of pancreas	UBERON:0001150	69.87	gold quality
right atrium auricular region	UBERON:0006631	69.21	gold quality
tibial artery	UBERON:0007610	67.11	gold quality
stomach	UBERON:0000945	66.81	gold quality
granulocyte	CL:0000094	66.68	gold quality
minor salivary gland	UBERON:0001830	66.54	gold quality
skin of abdomen	UBERON:0001416	65.80	gold quality
body of stomach	UBERON:0001161	65.70	gold quality
adult mammalian kidney	UBERON:0000082	65.20	gold quality
esophagus mucosa	UBERON:0002469	64.97	gold quality
cerebellar hemisphere	UBERON:0002245	64.88	gold quality
ascending aorta	UBERON:0001496	64.86	gold quality
muscle layer of sigmoid colon	UBERON:0035805	64.86	gold quality
putamen	UBERON:0001874	64.47	gold quality
spleen	UBERON:0002106	64.43	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	64.26	gold quality
right hemisphere of cerebellum	UBERON:0014890	64.25	gold quality
thoracic mammary gland	UBERON:0005200	64.11	gold quality
left ovary	UBERON:0002119	63.83	gold quality
tibial nerve	UBERON:0001323	63.72	gold quality
hypothalamus	UBERON:0001898	63.48	gold quality
fundus of stomach	UBERON:0001160	63.38	gold quality
omental fat pad	UBERON:0010414	63.35	gold quality
myometrium	UBERON:0001296	63.15	gold quality
skin of leg	UBERON:0001511	63.15	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.66

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.