MIR4672

Summary

MIR4672 (microRNA 4672, HGNC:41662) is a microRNA gene on chromosome 9q34.11.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616429 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41662
Approved symbol	MIR4672
Name	microRNA 4672
Location	9q34.11
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4672
Ensembl gene	ENSG00000263979
Ensembl biotype	miRNA
Entrez	100616429
RNAcentral	URS000075BBED — miRNA, 81 nt, 5 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000583126

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000583126 — 1 exons

Exon	Start	End
ENSE00002704125	127869415	127869495

Expression profiles

Bgee: expression breadth broad, 89 present calls, max score 91.04.

Top tissues by expression

89 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skeletal muscle tissue	UBERON:0001134	91.04	gold quality
vermiform appendix	UBERON:0001154	81.98	gold quality
muscle of leg	UBERON:0001383	81.62	gold quality
bone marrow	UBERON:0002371	81.47	gold quality
monocyte	CL:0000576	81.30	gold quality
lymph node	UBERON:0000029	79.19	gold quality
blood	UBERON:0000178	75.60	gold quality
corpus callosum	UBERON:0002336	73.12	gold quality
heart left ventricle	UBERON:0002084	73.08	gold quality
gastrocnemius	UBERON:0001388	72.62	gold quality
prefrontal cortex	UBERON:0000451	71.81	gold quality
right adrenal gland cortex	UBERON:0035827	71.81	gold quality
heart	UBERON:0000948	71.74	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	71.69	gold quality
endometrium	UBERON:0001295	71.43	gold quality
body of pancreas	UBERON:0001150	70.05	gold quality
right lobe of liver	UBERON:0001114	69.98	gold quality
body of stomach	UBERON:0001161	69.60	gold quality
liver	UBERON:0002107	69.54	gold quality
right atrium auricular region	UBERON:0006631	69.53	gold quality
left coronary artery	UBERON:0001626	69.40	gold quality
stomach	UBERON:0000945	68.90	gold quality
kidney	UBERON:0002113	68.25	gold quality
ectocervix	UBERON:0012249	67.92	gold quality
urinary bladder	UBERON:0001255	67.62	gold quality
transverse colon	UBERON:0001157	67.45	gold quality
left adrenal gland	UBERON:0001234	67.22	gold quality
rectum	UBERON:0001052	67.14	gold quality
apex of heart	UBERON:0002098	67.14	gold quality
colon	UBERON:0001155	67.12	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.13

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.