MIR4673

Summary

MIR4673 (microRNA 4673, HGNC:41574) is a microRNA gene on chromosome 9q34.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616242 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41574
Approved symbol	MIR4673
Name	microRNA 4673
Location	9q34.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4673
Ensembl gene	ENSG00000263403
Ensembl biotype	miRNA
Entrez	100616242
RNAcentral	URS0000759F90 — ncRNA, 59 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000584777

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000584777 — 1 exons

Exon	Start	End
ENSE00002698459	136519568	136519626

Expression profiles

Bgee: expression breadth broad, 64 present calls, max score 97.22.

Top tissues by expression

64 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	97.22	gold quality
skeletal muscle tissue	UBERON:0001134	91.06	gold quality
muscle of leg	UBERON:0001383	80.76	gold quality
blood	UBERON:0000178	80.09	gold quality
adrenal tissue	UBERON:0018303	79.77	gold quality
gastrocnemius	UBERON:0001388	73.92	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	71.04	gold quality
rectum	UBERON:0001052	70.82	gold quality
heart left ventricle	UBERON:0002084	70.03	gold quality
left adrenal gland	UBERON:0001234	69.76	gold quality
endometrium	UBERON:0001295	69.66	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	69.22	gold quality
heart	UBERON:0000948	68.97	gold quality
body of stomach	UBERON:0001161	68.95	gold quality
putamen	UBERON:0001874	68.93	gold quality
substantia nigra	UBERON:0002038	68.69	gold quality
ascending aorta	UBERON:0001496	68.59	gold quality
tibial artery	UBERON:0007610	68.51	gold quality
skin of leg	UBERON:0001511	68.36	gold quality
transverse colon	UBERON:0001157	68.34	gold quality
adult mammalian kidney	UBERON:0000082	68.21	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.88	gold quality
right atrium auricular region	UBERON:0006631	67.78	gold quality
stomach	UBERON:0000945	67.72	gold quality
body of uterus	UBERON:0009853	67.71	gold quality
omental fat pad	UBERON:0010414	67.34	gold quality
esophagus mucosa	UBERON:0002469	67.14	gold quality
amygdala	UBERON:0001876	67.09	gold quality
colon	UBERON:0001155	67.02	gold quality
skin of abdomen	UBERON:0001416	66.33	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.12

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• MiR4673 improves fitness profile and radiation resistance of SKBR3 cells by increasing mitophagy that enhances anti-oxidant capacity of the neoplastic cells. (PMID:30341280)
• MiRNA-4673 amplifies the neurogenic potential of notch-1 by reprogramming of the cell cycle of neural progenitors. (PMID:30907228)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.