MIR4674

Summary

MIR4674 (microRNA 4674, HGNC:41729) is a microRNA gene on chromosome 9q34.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616301 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41729
Approved symbol	MIR4674
Name	microRNA 4674
Location	9q34.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4674
Ensembl gene	ENSG00000265181
Ensembl biotype	miRNA
Entrez	100616301
RNAcentral	URS000075A2C1 — ncRNA, 87 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000582457

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000582457 — 1 exons

Exon	Start	End
ENSE00002688115	136546173	136546259

Expression profiles

Bgee: expression breadth broad, 72 present calls, max score 93.01.

Top tissues by expression

72 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	93.01	gold quality
right coronary artery	UBERON:0001625	76.90	gold quality
monocyte	CL:0000576	75.84	gold quality
gastrocnemius	UBERON:0001388	75.06	gold quality
heart left ventricle	UBERON:0002084	74.26	gold quality
right uterine tube	UBERON:0001302	72.80	gold quality
fundus of stomach	UBERON:0001160	72.61	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	71.29	gold quality
left adrenal gland cortex	UBERON:0035825	69.90	gold quality
right lobe of liver	UBERON:0001114	69.27	gold quality
adrenal gland	UBERON:0002369	69.10	gold quality
blood	UBERON:0000178	68.79	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.75	gold quality
tibial artery	UBERON:0007610	68.20	gold quality
popliteal artery	UBERON:0002250	68.18	gold quality
body of stomach	UBERON:0001161	68.05	gold quality
Ammon’s horn	UBERON:0001954	67.93	gold quality
lower esophagus	UBERON:0013473	67.83	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.83	gold quality
body of pancreas	UBERON:0001150	67.62	gold quality
Brodmann (1909) area 9	UBERON:0013540	67.51	gold quality
muscle layer of sigmoid colon	UBERON:0035805	67.50	gold quality
left adrenal gland	UBERON:0001234	67.46	gold quality
esophagus	UBERON:0001043	67.44	gold quality
left coronary artery	UBERON:0001626	67.41	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	67.40	gold quality
urinary bladder	UBERON:0001255	66.75	gold quality
thoracic aorta	UBERON:0001515	66.71	gold quality
ascending aorta	UBERON:0001496	66.62	gold quality
colon	UBERON:0001155	66.60	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.06

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Elevated plasma miR-4674 is associated with metastatic disease in castration-resistant prostate cancer. (PMID:27265126)
• Neutralization of miR-4674 increased angiogenesis and p38 phosphorylation in skin organoids as a model of tissue injury. (PMID:31913696)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.