MIR4675

Summary

MIR4675 (microRNA 4675, HGNC:41619) is a microRNA gene on chromosome 10p12.31.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616383 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41619
Approved symbol	MIR4675
Name	microRNA 4675
Location	10p12.31
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4675
Ensembl gene	ENSG00000265372
Ensembl biotype	miRNA
Entrez	100616383
RNAcentral	URS000075E335 — miRNA, 77 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000577898

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000577898 — 1 exons

Exon	Start	End
ENSE00002713406	20551970	20552046

Expression profiles

Bgee: expression breadth broad, 37 present calls, max score 90.65.

Top tissues by expression

37 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
calcaneal tendon	UBERON:0003701	90.65	gold quality
gastrocnemius	UBERON:0001388	74.06	gold quality
kidney	UBERON:0002113	74.00	gold quality
monocyte	CL:0000576	73.46	gold quality
sural nerve	UBERON:0015488	72.91	gold quality
right atrium auricular region	UBERON:0006631	69.06	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	69.04	gold quality
muscle layer of sigmoid colon	UBERON:0035805	68.94	gold quality
subcutaneous adipose tissue	UBERON:0002190	68.39	gold quality
ascending aorta	UBERON:0001496	66.99	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.63	gold quality
Ammon’s horn	UBERON:0001954	66.21	gold quality
skin of abdomen	UBERON:0001416	65.28	gold quality
body of stomach	UBERON:0001161	64.82	gold quality
right hemisphere of cerebellum	UBERON:0014890	64.13	gold quality
myometrium	UBERON:0001296	64.09	gold quality
upper lobe of left lung	UBERON:0008952	64.01	gold quality
esophagus mucosa	UBERON:0002469	63.87	gold quality
amygdala	UBERON:0001876	63.54	gold quality
right ovary	UBERON:0002118	63.31	gold quality
skin of leg	UBERON:0001511	63.25	gold quality
tibial artery	UBERON:0007610	62.92	gold quality
cerebellar hemisphere	UBERON:0002245	62.48	gold quality
omental fat pad	UBERON:0010414	62.26	gold quality
tibial nerve	UBERON:0001323	61.71	gold quality
vagina	UBERON:0000996	61.52	gold quality
left ovary	UBERON:0002119	61.36	gold quality
nucleus accumbens	UBERON:0001882	60.57	gold quality
prostate gland	UBERON:0002367	59.88	gold quality
left lobe of thyroid gland	UBERON:0001120	59.12	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.48

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.