MIR4676

Summary

MIR4676 (microRNA 4676, HGNC:41691) is a microRNA gene on chromosome 10q22.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616286 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41691
Approved symbol	MIR4676
Name	microRNA 4676
Location	10q22.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4676
Ensembl gene	ENSG00000266719
Ensembl biotype	miRNA
Entrez	100616286
RNAcentral	URS0000759E99 — miRNA, 72 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000583078

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000583078 — 1 exons

Exon	Start	End
ENSE00002692516	72721029	72721100

Expression profiles

Bgee: expression breadth broad, 45 present calls, max score 84.30.

Top tissues by expression

45 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	84.30	gold quality
kidney	UBERON:0002113	81.41	gold quality
calcaneal tendon	UBERON:0003701	79.49	gold quality
endometrium	UBERON:0001295	78.81	gold quality
blood	UBERON:0000178	76.31	gold quality
gastrocnemius	UBERON:0001388	74.94	gold quality
heart left ventricle	UBERON:0002084	70.77	gold quality
liver	UBERON:0002107	70.48	gold quality
intestine	UBERON:0000160	70.17	gold quality
hypothalamus	UBERON:0001898	70.10	gold quality
stomach	UBERON:0000945	68.74	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.05	gold quality
body of stomach	UBERON:0001161	66.71	gold quality
left adrenal gland	UBERON:0001234	66.11	gold quality
skin of leg	UBERON:0001511	65.92	gold quality
transverse colon	UBERON:0001157	65.69	gold quality
lower esophagus muscularis layer	UBERON:0035833	65.52	gold quality
lung	UBERON:0002048	65.28	gold quality
skin of abdomen	UBERON:0001416	64.09	gold quality
tibial artery	UBERON:0007610	63.82	gold quality
small intestine Peyer’s patch	UBERON:0003454	63.72	gold quality
thoracic aorta	UBERON:0001515	63.57	gold quality
esophagus mucosa	UBERON:0002469	62.57	gold quality
cerebellar hemisphere	UBERON:0002245	62.42	gold quality
spleen	UBERON:0002106	62.40	gold quality
right adrenal gland cortex	UBERON:0035827	62.27	gold quality
left ovary	UBERON:0002119	61.96	gold quality
right frontal lobe	UBERON:0002810	61.87	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	61.69	gold quality
amygdala	UBERON:0001876	61.49	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.61

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.