MIR4677

Summary

MIR4677 (microRNA 4677, HGNC:41844) is a microRNA gene on chromosome 1q43.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616343 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41844
Approved symbol	MIR4677
Name	microRNA 4677
Location	1q43
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4677
Ensembl gene	ENSG00000265201
Ensembl biotype	miRNA
Entrez	100616343
RNAcentral	URS000075ABD7 — miRNA, 80 nt, 17 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000584153

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000584153 — 1 exons

Exon	Start	End
ENSE00002734129	243346176	243346255

Expression profiles

Bgee: expression breadth ubiquitous, 102 present calls, max score 88.99.

Top tissues by expression

102 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
corpus callosum	UBERON:0002336	88.99	gold quality
adrenal tissue	UBERON:0018303	84.39	gold quality
calcaneal tendon	UBERON:0003701	84.29	gold quality
duodenum	UBERON:0002114	82.90	gold quality
granulocyte	CL:0000094	78.41	gold quality
monocyte	CL:0000576	77.65	gold quality
endometrium	UBERON:0001295	75.80	gold quality
blood	UBERON:0000178	75.56	gold quality
liver	UBERON:0002107	75.34	gold quality
muscle of leg	UBERON:0001383	75.10	gold quality
lymph node	UBERON:0000029	75.05	gold quality
placenta	UBERON:0001987	74.83	gold quality
tonsil	UBERON:0002372	74.80	gold quality
bone marrow	UBERON:0002371	74.27	gold quality
kidney	UBERON:0002113	73.54	gold quality
left uterine tube	UBERON:0001303	73.47	gold quality
gastrocnemius	UBERON:0001388	73.38	gold quality
lung	UBERON:0002048	72.39	gold quality
adult mammalian kidney	UBERON:0000082	72.28	gold quality
endocervix	UBERON:0000458	72.05	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	71.65	gold quality
islet of Langerhans	UBERON:0000006	71.64	gold quality
stomach	UBERON:0000945	71.62	gold quality
right lobe of liver	UBERON:0001114	71.27	gold quality
adrenal gland	UBERON:0002369	71.27	gold quality
body of pancreas	UBERON:0001150	71.24	gold quality
ovary	UBERON:0000992	71.18	gold quality
left ovary	UBERON:0002119	71.10	gold quality
myometrium	UBERON:0001296	70.97	gold quality
heart	UBERON:0000948	70.91	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 8)

• LncRNA TTN-AS1 drives invasion and migration of lung adenocarcinoma cells via modulation of miR-4677-3p/ZEB1 axis. (PMID:31173403)
• LncRNA LINC02418 regulates proliferation and apoptosis of non-small cell lung cancer cells by regulating miR-4677-3p/SEC61G. (PMID:31841189)
• LINC02418 promotes malignant behaviors in lung adenocarcinoma cells by sponging miR-4677-3p to upregulate KNL1 expression. (PMID:32795273)
• Circ_0001421 facilitates glycolysis and lung cancer development by regulating miR-4677-3p/CDCA3. (PMID:33109222)
• GLIDR promotes the progression of glioma by regulating the miR-4677-3p/MAGI2 axis. (PMID:34237299)
• miR-4677-3p participates proliferation and metastases of gastric cancer cell via CEMIP-PI3K/AKT signaling pathway. (PMID:34437815)
• LINC00265 promotes the viability, proliferation, and migration of bladder cancer cells via the miR-4677-3p/FGF6 axis. (PMID:34591706)
• Knockdown of circ_0044226 promotes endoplasmic reticulum stress-mediated autophagy and apoptosis in hepatic stellate cells via miR-4677-3p/SEC61G axis. (PMID:38421527)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.