MIR4678

Summary

MIR4678 (microRNA 4678, HGNC:41717) is a microRNA gene on chromosome 10q23.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616296 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41717
Approved symbol	MIR4678
Name	microRNA 4678
Location	10q23.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4678
Ensembl gene	ENSG00000283672
Ensembl biotype	miRNA
Entrez	100616296
RNAcentral	URS000075D7E9 — miRNA, 74 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000636979

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000636979 — 1 exons

Exon	Start	End
ENSE00003799305	87503881	87503954

Expression profiles

Bgee: expression breadth broad, 96 present calls, max score 85.78.

Top tissues by expression

96 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow	UBERON:0002371	85.78	gold quality
skeletal muscle tissue	UBERON:0001134	85.00	gold quality
calcaneal tendon	UBERON:0003701	84.90	gold quality
lymph node	UBERON:0000029	78.85	gold quality
adrenal tissue	UBERON:0018303	78.32	gold quality
blood	UBERON:0000178	77.90	gold quality
placenta	UBERON:0001987	76.45	gold quality
monocyte	CL:0000576	75.21	gold quality
muscle of leg	UBERON:0001383	74.15	gold quality
islet of Langerhans	UBERON:0000006	73.56	gold quality
gastrocnemius	UBERON:0001388	72.90	gold quality
descending thoracic aorta	UBERON:0002345	72.87	gold quality
tonsil	UBERON:0002372	71.31	gold quality
heart left ventricle	UBERON:0002084	71.24	gold quality
kidney	UBERON:0002113	71.02	gold quality
rectum	UBERON:0001052	70.92	gold quality
stomach	UBERON:0000945	70.82	gold quality
endometrium	UBERON:0001295	70.76	gold quality
heart	UBERON:0000948	70.44	gold quality
right lobe of liver	UBERON:0001114	70.37	gold quality
prefrontal cortex	UBERON:0000451	70.32	gold quality
adrenal gland	UBERON:0002369	70.20	gold quality
Brodmann (1909) area 9	UBERON:0013540	70.20	gold quality
fundus of stomach	UBERON:0001160	69.97	gold quality
left adrenal gland	UBERON:0001234	69.77	gold quality
body of stomach	UBERON:0001161	69.50	gold quality
left coronary artery	UBERON:0001626	69.17	gold quality
left adrenal gland cortex	UBERON:0035825	68.83	gold quality
tibial artery	UBERON:0007610	68.80	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	68.72	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.12

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.