MIR4679-2

Summary

MIR4679-2 (microRNA 4679-2, HGNC:41890) is a microRNA gene on chromosome 10q23.31.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616192 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41890
Approved symbol	MIR4679-2
Name	microRNA 4679-2
Location	10q23.31
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4679-2
Ensembl gene	ENSG00000265375
Ensembl biotype	miRNA
Entrez	100616192
RNAcentral	URS000075CD7E — ncRNA, 77 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000578358

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000578358 — 1 exons

Exon	Start	End
ENSE00002694419	89063335	89063411

Expression profiles

Bgee: expression breadth broad, 30 present calls, max score 72.99.

Top tissues by expression

30 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	72.99	gold quality
monocyte	CL:0000576	72.64	gold quality
Brodmann (1909) area 9	UBERON:0013540	72.29	gold quality
right ovary	UBERON:0002118	69.63	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	69.29	gold quality
endometrium	UBERON:0001295	69.14	gold quality
right adrenal gland	UBERON:0001233	67.85	gold quality
tibial nerve	UBERON:0001323	67.83	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	67.51	gold quality
left adrenal gland	UBERON:0001234	67.39	gold quality
omental fat pad	UBERON:0010414	65.51	gold quality
skin of abdomen	UBERON:0001416	64.92	gold quality
right frontal lobe	UBERON:0002810	64.81	gold quality
body of stomach	UBERON:0001161	64.55	gold quality
ascending aorta	UBERON:0001496	64.02	gold quality
transverse colon	UBERON:0001157	63.69	gold quality
amygdala	UBERON:0001876	63.49	gold quality
tibial artery	UBERON:0007610	63.49	gold quality
caudate nucleus	UBERON:0001873	62.87	gold quality
vagina	UBERON:0000996	62.66	gold quality
cerebellar hemisphere	UBERON:0002245	62.08	gold quality
anterior cingulate cortex	UBERON:0009835	60.51	gold quality
pituitary gland	UBERON:0000007	59.74	gold quality
spleen	UBERON:0002106	59.59	gold quality
small intestine Peyer’s patch	UBERON:0003454	59.49	gold quality
thyroid gland	UBERON:0002046	59.44	gold quality
left lobe of thyroid gland	UBERON:0001120	57.58	gold quality
esophagus mucosa	UBERON:0002469	57.33	gold quality
left ovary	UBERON:0002119	55.56	gold quality
left testis	UBERON:0004533	47.51	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.13

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.