MIR4681

Summary

MIR4681 (microRNA 4681, HGNC:41753) is a microRNA gene on chromosome 10q26.11.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616398 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41753
Approved symbol	MIR4681
Name	microRNA 4681
Location	10q26.11
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4681
Ensembl gene	ENSG00000265719
Ensembl biotype	miRNA
Entrez	100616398
RNAcentral	URS000075AED4 — ncRNA, 72 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000580598

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000580598 — 1 exons

Exon	Start	End
ENSE00002729001	119377972	119378043

Expression profiles

Bgee: expression breadth broad, 68 present calls, max score 83.84.

Top tissues by expression

68 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	83.84	gold quality
bone marrow	UBERON:0002371	81.24	gold quality
right lobe of thyroid gland	UBERON:0001119	78.15	gold quality
blood	UBERON:0000178	76.29	gold quality
liver	UBERON:0002107	75.92	gold quality
kidney	UBERON:0002113	75.37	gold quality
gastrocnemius	UBERON:0001388	74.47	gold quality
right atrium auricular region	UBERON:0006631	72.02	gold quality
monocyte	CL:0000576	71.37	gold quality
heart	UBERON:0000948	70.84	gold quality
stomach	UBERON:0000945	69.54	gold quality
heart left ventricle	UBERON:0002084	69.39	gold quality
tibial artery	UBERON:0007610	68.66	gold quality
popliteal artery	UBERON:0002250	68.61	gold quality
endometrium	UBERON:0001295	67.37	gold quality
Ammon’s horn	UBERON:0001954	67.29	gold quality
left adrenal gland cortex	UBERON:0035825	66.79	gold quality
body of stomach	UBERON:0001161	66.72	gold quality
left adrenal gland	UBERON:0001234	66.67	gold quality
granulocyte	CL:0000094	66.48	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.17	gold quality
ascending aorta	UBERON:0001496	66.11	gold quality
muscle layer of sigmoid colon	UBERON:0035805	65.90	gold quality
left coronary artery	UBERON:0001626	65.89	gold quality
colon	UBERON:0001155	65.81	gold quality
right lobe of liver	UBERON:0001114	65.59	gold quality
esophagus mucosa	UBERON:0002469	65.55	gold quality
lung	UBERON:0002048	65.29	gold quality
body of uterus	UBERON:0009853	65.06	gold quality
amygdala	UBERON:0001876	64.96	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.32

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.