MIR4682

Summary

MIR4682 (microRNA 4682, HGNC:41788) is a microRNA gene on chromosome 10q26.12.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616322 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41788
Approved symbol	MIR4682
Name	microRNA 4682
Location	10q26.12
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4682
Ensembl gene	ENSG00000265370
Ensembl biotype	miRNA
Entrez	100616322
RNAcentral	URS000075D2E3 — ncRNA, 80 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000580643

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000580643 — 1 exons

Exon	Start	End
ENSE00002714819	119958513	119958592

Expression profiles

Bgee: expression breadth broad, 87 present calls, max score 97.17.

Top tissues by expression

87 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	97.17	gold quality
islet of Langerhans	UBERON:0000006	76.47	gold quality
muscle of leg	UBERON:0001383	74.96	gold quality
fundus of stomach	UBERON:0001160	74.59	gold quality
gastrocnemius	UBERON:0001388	74.49	gold quality
right lobe of liver	UBERON:0001114	73.70	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	72.53	gold quality
blood	UBERON:0000178	71.96	gold quality
monocyte	CL:0000576	71.60	gold quality
left uterine tube	UBERON:0001303	70.71	gold quality
endometrium	UBERON:0001295	70.52	gold quality
heart left ventricle	UBERON:0002084	70.46	gold quality
heart	UBERON:0000948	70.06	gold quality
right atrium auricular region	UBERON:0006631	69.87	gold quality
endocervix	UBERON:0000458	69.54	gold quality
fallopian tube	UBERON:0003889	69.31	gold quality
right uterine tube	UBERON:0001302	68.99	gold quality
stomach	UBERON:0000945	68.75	gold quality
Brodmann (1909) area 9	UBERON:0013540	68.58	gold quality
amygdala	UBERON:0001876	68.27	gold quality
body of stomach	UBERON:0001161	68.22	gold quality
mucosa of stomach	UBERON:0001199	68.22	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	68.19	gold quality
body of pancreas	UBERON:0001150	68.01	gold quality
urinary bladder	UBERON:0001255	67.99	gold quality
left adrenal gland cortex	UBERON:0035825	67.89	gold quality
substantia nigra	UBERON:0002038	67.84	gold quality
granulocyte	CL:0000094	67.76	gold quality
tibial artery	UBERON:0007610	67.64	gold quality
left coronary artery	UBERON:0001626	67.54	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.30

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.