MIR4683

Summary

MIR4683 (microRNA 4683, HGNC:41883) is a microRNA gene on chromosome 10p11.21.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616500 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41883
Approved symbol	MIR4683
Name	microRNA 4683
Location	10p11.21
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4683
Ensembl gene	ENSG00000284265
Ensembl biotype	miRNA
Entrez	100616500
RNAcentral	URS000075B755 — miRNA, 81 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000579659

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000579659 — 1 exons

Exon	Start	End
ENSE00002699699	35641172	35641252

Expression profiles

Bgee: expression breadth broad, 22 present calls, max score 91.35.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.1880 / max 54.1666, expressed in 73 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
109107	0.1880	73

Top tissues by expression

22 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	91.35	gold quality
heart	UBERON:0000948	85.64	gold quality
tibial artery	UBERON:0007610	69.61	gold quality
blood	UBERON:0000178	68.93	gold quality
gastrocnemius	UBERON:0001388	68.26	gold quality
body of stomach	UBERON:0001161	68.09	gold quality
stomach	UBERON:0000945	67.32	gold quality
lung	UBERON:0002048	64.11	gold quality
vagina	UBERON:0000996	62.20	gold quality
multicellular organism	UBERON:0000468	60.09	gold quality
substantia nigra	UBERON:0002038	58.69	gold quality
left adrenal gland cortex	UBERON:0035825	58.26	gold quality
body of pancreas	UBERON:0001150	57.66	gold quality
esophagus mucosa	UBERON:0002469	56.42	gold quality
brain	UBERON:0000955	54.46	gold quality
Ammon’s horn	UBERON:0001954	50.67	gold quality
urinary bladder	UBERON:0001255	49.23	gold quality
right ovary	UBERON:0002118	48.50	gold quality
pituitary gland	UBERON:0000007	48.40	gold quality
left ovary	UBERON:0002119	47.58	gold quality
body of uterus	UBERON:0009853	45.39	gold quality
putamen	UBERON:0001874	43.27	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.