MIR4684

Summary

MIR4684 (microRNA 4684, HGNC:41695) is a microRNA gene on chromosome 1p36.12.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616391 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41695
Approved symbol	MIR4684
Name	microRNA 4684
Location	1p36.12
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4684
Ensembl gene	ENSG00000265422
Ensembl biotype	miRNA
Entrez	100616391
RNAcentral	URS000075C836 — ncRNA, 82 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000581646

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000581646 — 1 exons

Exon	Start	End
ENSE00002721039	22719517	22719598

Expression profiles

Bgee: expression breadth broad, 23 present calls, max score 86.16.

Top tissues by expression

23 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	86.16	gold quality
adrenal tissue	UBERON:0018303	81.00	gold quality
stomach	UBERON:0000945	78.49	gold quality
muscle of leg	UBERON:0001383	77.79	gold quality
kidney	UBERON:0002113	76.24	gold quality
heart	UBERON:0000948	73.53	gold quality
lung	UBERON:0002048	71.96	gold quality
anterior cingulate cortex	UBERON:0009835	64.50	gold quality
minor salivary gland	UBERON:0001830	64.45	gold quality
intestine	UBERON:0000160	63.86	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	63.68	gold quality
tibial artery	UBERON:0007610	62.70	gold quality
left ovary	UBERON:0002119	62.49	gold quality
small intestine Peyer’s patch	UBERON:0003454	61.14	gold quality
substantia nigra	UBERON:0002038	60.34	gold quality
left lobe of thyroid gland	UBERON:0001120	60.18	gold quality
thyroid gland	UBERON:0002046	59.02	gold quality
brain	UBERON:0000955	58.80	gold quality
hypothalamus	UBERON:0001898	58.79	gold quality
corpus callosum	UBERON:0002336	54.36	gold quality
muscle layer of sigmoid colon	UBERON:0035805	53.10	gold quality
right testis	UBERON:0004534	45.92	gold quality
left testis	UBERON:0004533	44.15	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.86

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.