MIR4685

Summary

MIR4685 (microRNA 4685, HGNC:41802) is a microRNA gene on chromosome 10q24.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616482 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41802
Approved symbol	MIR4685
Name	microRNA 4685
Location	10q24.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4685
Ensembl gene	ENSG00000264610
Ensembl biotype	miRNA
Entrez	100616482
RNAcentral	URS000075D92E — ncRNA, 69 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000578185

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000578185 — 1 exons

Exon	Start	End
ENSE00002727223	98431292	98431360

Expression profiles

Bgee: expression breadth ubiquitous, 111 present calls, max score 88.37.

Top tissues by expression

111 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	88.37	gold quality
vermiform appendix	UBERON:0001154	88.08	gold quality
skeletal muscle tissue	UBERON:0001134	86.07	gold quality
apex of heart	UBERON:0002098	84.05	gold quality
bone marrow	UBERON:0002371	81.69	gold quality
blood	UBERON:0000178	81.30	gold quality
rectum	UBERON:0001052	80.07	gold quality
monocyte	CL:0000576	79.61	gold quality
lymph node	UBERON:0000029	79.07	gold quality
granulocyte	CL:0000094	79.02	gold quality
placenta	UBERON:0001987	78.30	gold quality
saliva-secreting gland	UBERON:0001044	77.80	gold quality
minor salivary gland	UBERON:0001830	77.61	gold quality
calcaneal tendon	UBERON:0003701	77.21	gold quality
spleen	UBERON:0002106	76.54	gold quality
body of stomach	UBERON:0001161	76.21	gold quality
small intestine	UBERON:0002108	75.78	gold quality
tonsil	UBERON:0002372	75.72	gold quality
transverse colon	UBERON:0001157	75.68	gold quality
stomach	UBERON:0000945	75.67	gold quality
small intestine Peyer’s patch	UBERON:0003454	75.50	gold quality
right lobe of thyroid gland	UBERON:0001119	75.44	gold quality
myometrium	UBERON:0001296	75.27	gold quality
prostate gland	UBERON:0002367	75.08	gold quality
smooth muscle tissue	UBERON:0001135	75.06	gold quality
intestine	UBERON:0000160	74.76	gold quality
endocervix	UBERON:0000458	74.74	gold quality
muscle of leg	UBERON:0001383	74.60	gold quality
body of pancreas	UBERON:0001150	74.55	gold quality
colon	UBERON:0001155	74.18	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.29

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• LncRNA LBX2-AS1 facilitates abdominal aortic aneurysm through miR-4685-5p/LBX2 feedback loop. (PMID:32559617)
• miR-4685-3p Alleviates Human Brain Microvascular Endothelial Cells Injury by Regulating MMP9. (PMID:38802152)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.