MIR4686

Summary

MIR4686 (microRNA 4686, HGNC:41601) is a microRNA gene on chromosome 11p15.5.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616126 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41601
Approved symbol	MIR4686
Name	microRNA 4686
Location	11p15.5
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4686
Ensembl gene	ENSG00000265258
Ensembl biotype	miRNA
Entrez	100616126
RNAcentral	URS000075D716 — ncRNA, 76 nt, 5 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000584128

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000584128 — 1 exons

Exon	Start	End
ENSE00002731462	2173063	2173138

Expression profiles

Bgee: expression breadth broad, 49 present calls, max score 76.71.

Top tissues by expression

49 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
liver	UBERON:0002107	76.71	gold quality
gastrocnemius	UBERON:0001388	75.89	gold quality
right lobe of liver	UBERON:0001114	75.19	gold quality
right adrenal gland	UBERON:0001233	74.94	gold quality
blood	UBERON:0000178	73.51	gold quality
islet of Langerhans	UBERON:0000006	73.45	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	73.16	gold quality
adrenal gland	UBERON:0002369	72.79	gold quality
body of pancreas	UBERON:0001150	71.87	gold quality
muscle layer of sigmoid colon	UBERON:0035805	71.87	gold quality
minor salivary gland	UBERON:0001830	70.81	gold quality
left adrenal gland	UBERON:0001234	70.09	gold quality
Ammon’s horn	UBERON:0001954	69.95	gold quality
Brodmann (1909) area 9	UBERON:0013540	68.85	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.53	gold quality
left adrenal gland cortex	UBERON:0035825	68.51	gold quality
endometrium	UBERON:0001295	68.48	gold quality
skin of abdomen	UBERON:0001416	68.04	gold quality
zone of skin	UBERON:0000014	67.48	gold quality
stomach	UBERON:0000945	67.05	gold quality
skin of leg	UBERON:0001511	66.92	gold quality
tibial nerve	UBERON:0001323	66.69	gold quality
anterior cingulate cortex	UBERON:0009835	66.04	gold quality
pituitary gland	UBERON:0000007	65.51	gold quality
lower esophagus mucosa	UBERON:0035834	65.22	gold quality
body of stomach	UBERON:0001161	65.19	gold quality
hypothalamus	UBERON:0001898	64.74	gold quality
lower esophagus muscularis layer	UBERON:0035833	64.69	gold quality
vagina	UBERON:0000996	64.48	gold quality
multicellular organism	UBERON:0000468	64.34	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.33

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.