MIR4688

Summary

MIR4688 (microRNA 4688, HGNC:41897) is a microRNA gene on chromosome 11p11.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616368 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41897
Approved symbol	MIR4688
Name	microRNA 4688
Location	11p11.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4688
Ensembl gene	ENSG00000264102
Ensembl biotype	miRNA
Entrez	100616368
RNAcentral	URS000075E114 — ncRNA, 83 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000577966

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000577966 — 1 exons

Exon	Start	End
ENSE00002695927	46376402	46376484

Expression profiles

Bgee: expression breadth broad, 88 present calls, max score 94.66.

Top tissues by expression

88 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	94.66	gold quality
skeletal muscle tissue	UBERON:0001134	82.23	gold quality
granulocyte	CL:0000094	82.17	gold quality
vermiform appendix	UBERON:0001154	79.42	gold quality
lymph node	UBERON:0000029	78.78	gold quality
bone marrow	UBERON:0002371	78.46	gold quality
blood	UBERON:0000178	76.82	gold quality
muscle of leg	UBERON:0001383	76.33	gold quality
gastrocnemius	UBERON:0001388	75.83	gold quality
monocyte	CL:0000576	75.15	gold quality
right adrenal gland cortex	UBERON:0035827	74.69	gold quality
adrenal tissue	UBERON:0018303	74.41	gold quality
islet of Langerhans	UBERON:0000006	74.19	gold quality
apex of heart	UBERON:0002098	73.19	gold quality
prefrontal cortex	UBERON:0000451	73.15	gold quality
right atrium auricular region	UBERON:0006631	72.41	gold quality
heart	UBERON:0000948	71.74	gold quality
heart left ventricle	UBERON:0002084	71.32	gold quality
body of stomach	UBERON:0001161	71.13	gold quality
stomach	UBERON:0000945	71.03	gold quality
metanephros cortex	UBERON:0010533	70.76	gold quality
right lobe of liver	UBERON:0001114	70.44	gold quality
liver	UBERON:0002107	70.43	gold quality
body of pancreas	UBERON:0001150	69.51	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	69.31	gold quality
right adrenal gland	UBERON:0001233	69.22	gold quality
right frontal lobe	UBERON:0002810	69.11	gold quality
tibial artery	UBERON:0007610	69.07	gold quality
left coronary artery	UBERON:0001626	68.56	gold quality
endometrium	UBERON:0001295	68.13	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.