MIR4689

Summary

MIR4689 (microRNA 4689, HGNC:41895) is a microRNA gene on chromosome 1p36.31.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616421 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41895
Approved symbol	MIR4689
Name	microRNA 4689
Location	1p36.31
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4689
Ensembl gene	ENSG00000264101
Ensembl biotype	miRNA
Entrez	100616421
RNAcentral	URS000075C134 — miRNA, 70 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000582517

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000582517 — 1 exons

Exon	Start	End
ENSE00002689481	5862672	5862741

Expression profiles

Bgee: expression breadth broad, 76 present calls, max score 80.48.

Top tissues by expression

76 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow	UBERON:0002371	80.48	gold quality
adenohypophysis	UBERON:0002196	76.89	gold quality
pituitary gland	UBERON:0000007	76.71	gold quality
blood	UBERON:0000178	76.50	gold quality
calcaneal tendon	UBERON:0003701	76.41	gold quality
descending thoracic aorta	UBERON:0002345	73.30	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	73.23	gold quality
monocyte	CL:0000576	72.93	gold quality
gastrocnemius	UBERON:0001388	72.64	gold quality
endometrium	UBERON:0001295	71.77	gold quality
pancreas	UBERON:0001264	70.78	gold quality
right uterine tube	UBERON:0001302	70.46	gold quality
right lobe of liver	UBERON:0001114	70.43	gold quality
body of pancreas	UBERON:0001150	70.27	gold quality
heart left ventricle	UBERON:0002084	70.16	gold quality
stomach	UBERON:0000945	69.63	gold quality
liver	UBERON:0002107	69.60	gold quality
skin of abdomen	UBERON:0001416	69.46	gold quality
ectocervix	UBERON:0012249	69.43	gold quality
left adrenal gland cortex	UBERON:0035825	69.37	gold quality
body of stomach	UBERON:0001161	69.25	gold quality
heart	UBERON:0000948	69.15	gold quality
left adrenal gland	UBERON:0001234	69.07	gold quality
zone of skin	UBERON:0000014	68.77	gold quality
fundus of stomach	UBERON:0001160	68.77	gold quality
myometrium	UBERON:0001296	68.76	gold quality
popliteal artery	UBERON:0002250	68.28	gold quality
tibial artery	UBERON:0007610	68.28	gold quality
adult mammalian kidney	UBERON:0000082	68.20	gold quality
thoracic aorta	UBERON:0001515	68.13	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Hypoxia-induced long non-coding RNA LINC00460 promotes p53 mediated proliferation and metastasis of pancreatic cancer by regulating the miR-4689/UBE2V1 axis and sequestering USP10. (PMID:37786443)
• CircPTPN22 modulates T-cell activation by sponging miR-4689 to regulate S1PR1 expression in patients with systemic lupus erythematosus. (PMID:37858140)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.