MIR4690

Summary

MIR4690 (microRNA 4690, HGNC:41707) is a microRNA gene on chromosome 11q13.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616292 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41707
Approved symbol	MIR4690
Name	microRNA 4690
Location	11q13.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4690
Ensembl gene	ENSG00000266041
Ensembl biotype	miRNA
Entrez	100616292
RNAcentral	URS000075EF83 — miRNA, 60 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000578459

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000578459 — 1 exons

Exon	Start	End
ENSE00002695352	65636310	65636369

Expression profiles

Bgee: expression breadth ubiquitous, 103 present calls, max score 87.55.

Top tissues by expression

103 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	87.55	gold quality
vermiform appendix	UBERON:0001154	84.77	gold quality
duodenum	UBERON:0002114	83.45	gold quality
bone marrow	UBERON:0002371	83.24	gold quality
lymph node	UBERON:0000029	81.75	gold quality
prefrontal cortex	UBERON:0000451	81.72	gold quality
granulocyte	CL:0000094	80.49	gold quality
blood	UBERON:0000178	80.26	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	79.00	gold quality
monocyte	CL:0000576	78.86	gold quality
lower esophagus mucosa	UBERON:0035834	77.34	gold quality
spleen	UBERON:0002106	76.69	gold quality
smooth muscle tissue	UBERON:0001135	76.51	gold quality
placenta	UBERON:0001987	76.02	gold quality
muscle of leg	UBERON:0001383	75.94	gold quality
gastrocnemius	UBERON:0001388	75.41	gold quality
rectum	UBERON:0001052	74.71	gold quality
right lobe of liver	UBERON:0001114	74.61	gold quality
transverse colon	UBERON:0001157	73.85	gold quality
body of stomach	UBERON:0001161	73.72	gold quality
small intestine	UBERON:0002108	73.66	gold quality
prostate gland	UBERON:0002367	73.65	gold quality
heart left ventricle	UBERON:0002084	73.61	gold quality
stomach	UBERON:0000945	73.54	gold quality
skin of leg	UBERON:0001511	73.34	gold quality
liver	UBERON:0002107	73.21	gold quality
small intestine Peyer’s patch	UBERON:0003454	73.19	gold quality
kidney	UBERON:0002113	73.13	gold quality
zone of skin	UBERON:0000014	73.09	gold quality
popliteal artery	UBERON:0002250	73.02	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.04

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.