MIR4691

Summary

MIR4691 (microRNA 4691, HGNC:41796) is a microRNA gene on chromosome 11q13.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616403 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41796
Approved symbol	MIR4691
Name	microRNA 4691
Location	11q13.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4691
Ensembl gene	ENSG00000284435
Ensembl biotype	miRNA
Entrez	100616403
RNAcentral	URS000075C981 — ncRNA, 85 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000583764

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000583764 — 1 exons

Exon	Start	End
ENSE00002694269	68033897	68033981

Expression profiles

Bgee: expression breadth broad, 40 present calls, max score 82.43.

Top tissues by expression

40 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skeletal muscle tissue	UBERON:0001134	82.43	gold quality
islet of Langerhans	UBERON:0000006	70.37	gold quality
blood	UBERON:0000178	69.46	gold quality
right atrium auricular region	UBERON:0006631	69.05	gold quality
minor salivary gland	UBERON:0001830	68.94	gold quality
muscle of leg	UBERON:0001383	66.56	gold quality
gastrocnemius	UBERON:0001388	65.40	gold quality
body of stomach	UBERON:0001161	64.37	gold quality
heart left ventricle	UBERON:0002084	64.27	gold quality
small intestine Peyer’s patch	UBERON:0003454	63.04	gold quality
left lobe of thyroid gland	UBERON:0001120	61.66	gold quality
endometrium	UBERON:0001295	61.31	gold quality
tibial artery	UBERON:0007610	60.83	gold quality
anterior cingulate cortex	UBERON:0009835	60.67	gold quality
hypothalamus	UBERON:0001898	59.63	gold quality
skin of leg	UBERON:0001511	59.10	gold quality
substantia nigra	UBERON:0002038	59.08	gold quality
placenta	UBERON:0001987	58.44	gold quality
esophagus mucosa	UBERON:0002469	58.10	gold quality
lower esophagus muscularis layer	UBERON:0035833	57.78	gold quality
left ovary	UBERON:0002119	57.23	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	56.82	gold quality
putamen	UBERON:0001874	56.63	gold quality
sural nerve	UBERON:0015488	55.64	silver quality
Ammon’s horn	UBERON:0001954	54.52	gold quality
brain	UBERON:0000955	53.47	gold quality
skin of abdomen	UBERON:0001416	52.94	gold quality
omental fat pad	UBERON:0010414	51.98	gold quality
transverse colon	UBERON:0001157	51.46	gold quality
nucleus accumbens	UBERON:0001882	51.01	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• TPRG1-AS1 induces RBM24 expression and inhibits liver cancer progression by sponging miR-4691-5p and miR-3659. (PMID:34328265)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.