MIR4692

Summary

MIR4692 (microRNA 4692, HGNC:41856) is a microRNA gene on chromosome 11q13.4.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616410 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41856
Approved symbol	MIR4692
Name	microRNA 4692
Location	11q13.4
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4692
Ensembl gene	ENSG00000265064
Ensembl biotype	miRNA
Entrez	100616410
RNAcentral	URS000075C1CE — ncRNA, 63 nt, 5 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000583200

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000583200 — 1 exons

Exon	Start	End
ENSE00002727603	72783530	72783592

Expression profiles

Bgee: expression breadth broad, 69 present calls, max score 81.12.

Top tissues by expression

69 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lymph node	UBERON:0000029	81.12	gold quality
blood	UBERON:0000178	78.71	gold quality
adrenal tissue	UBERON:0018303	78.47	gold quality
heart	UBERON:0000948	76.83	gold quality
gastrocnemius	UBERON:0001388	76.78	gold quality
placenta	UBERON:0001987	74.08	gold quality
liver	UBERON:0002107	72.81	gold quality
right lobe of liver	UBERON:0001114	72.17	gold quality
islet of Langerhans	UBERON:0000006	71.84	gold quality
subcutaneous adipose tissue	UBERON:0002190	70.98	gold quality
stomach	UBERON:0000945	70.96	gold quality
monocyte	CL:0000576	70.70	gold quality
rectum	UBERON:0001052	70.53	gold quality
lower esophagus muscularis layer	UBERON:0035833	70.50	gold quality
body of stomach	UBERON:0001161	70.35	gold quality
body of pancreas	UBERON:0001150	70.25	gold quality
left adrenal gland cortex	UBERON:0035825	69.77	gold quality
urinary bladder	UBERON:0001255	69.06	gold quality
Ammon’s horn	UBERON:0001954	68.78	gold quality
granulocyte	CL:0000094	68.50	gold quality
gall bladder	UBERON:0002110	68.24	gold quality
transverse colon	UBERON:0001157	68.05	gold quality
colon	UBERON:0001155	67.95	gold quality
left adrenal gland	UBERON:0001234	67.55	gold quality
myometrium	UBERON:0001296	67.55	gold quality
intestine	UBERON:0000160	67.40	gold quality
kidney	UBERON:0002113	67.39	gold quality
hypothalamus	UBERON:0001898	67.27	gold quality
muscle layer of sigmoid colon	UBERON:0035805	67.26	gold quality
tibial nerve	UBERON:0001323	67.00	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.16

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.