MIR4693

Summary

MIR4693 (microRNA 4693, HGNC:41818) is a microRNA gene on chromosome 11q22.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616457 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41818
Approved symbol	MIR4693
Name	microRNA 4693
Location	11q22.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4693
Ensembl gene	ENSG00000264200
Ensembl biotype	miRNA
Entrez	100616457
RNAcentral	URS000075C27E — ncRNA, 75 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000578405

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000578405 — 1 exons

Exon	Start	End
ENSE00002707470	103849906	103849980

Expression profiles

Bgee: expression breadth broad, 41 present calls, max score 78.39.

Top tissues by expression

41 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	78.39	gold quality
blood	UBERON:0000178	76.21	gold quality
right lobe of liver	UBERON:0001114	72.66	gold quality
heart	UBERON:0000948	70.87	gold quality
right atrium auricular region	UBERON:0006631	69.61	gold quality
tibial artery	UBERON:0007610	69.20	gold quality
left adrenal gland	UBERON:0001234	69.09	gold quality
stomach	UBERON:0000945	68.81	gold quality
left coronary artery	UBERON:0001626	68.72	gold quality
skin of abdomen	UBERON:0001416	68.63	gold quality
gastrocnemius	UBERON:0001388	68.49	gold quality
body of pancreas	UBERON:0001150	68.02	gold quality
left adrenal gland cortex	UBERON:0035825	67.96	gold quality
heart left ventricle	UBERON:0002084	67.80	gold quality
thoracic aorta	UBERON:0001515	67.03	gold quality
ascending aorta	UBERON:0001496	67.01	gold quality
intestine	UBERON:0000160	66.76	gold quality
omental fat pad	UBERON:0010414	66.48	gold quality
transverse colon	UBERON:0001157	65.89	gold quality
esophagus mucosa	UBERON:0002469	64.85	gold quality
thoracic mammary gland	UBERON:0005200	64.24	gold quality
colon	UBERON:0001155	64.03	gold quality
left ovary	UBERON:0002119	63.90	gold quality
subcutaneous adipose tissue	UBERON:0002190	63.44	gold quality
lower esophagus muscularis layer	UBERON:0035833	63.15	gold quality
skin of leg	UBERON:0001511	62.95	gold quality
prostate gland	UBERON:0002367	62.92	gold quality
right ovary	UBERON:0002118	61.97	gold quality
left lobe of thyroid gland	UBERON:0001120	61.21	gold quality
minor salivary gland	UBERON:0001830	61.16	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.99

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.