MIR4694

Summary

MIR4694 (microRNA 4694, HGNC:41586) is a microRNA gene on chromosome 11p15.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616426 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41586
Approved symbol	MIR4694
Name	microRNA 4694
Location	11p15.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4694
Ensembl gene	ENSG00000264309
Ensembl biotype	miRNA
Entrez	100616426
RNAcentral	URS000075DCE5 — miRNA, 80 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000578534

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000578534 — 1 exons

Exon	Start	End
ENSE00002685030	19760004	19760083

Expression profiles

Bgee: expression breadth broad, 63 present calls, max score 91.45.

Top tissues by expression

63 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	91.45	gold quality
calcaneal tendon	UBERON:0003701	82.55	gold quality
blood	UBERON:0000178	77.96	gold quality
stomach	UBERON:0000945	76.95	gold quality
adrenal tissue	UBERON:0018303	75.67	gold quality
liver	UBERON:0002107	73.15	gold quality
gastrocnemius	UBERON:0001388	72.38	gold quality
esophagus mucosa	UBERON:0002469	69.77	gold quality
endometrium	UBERON:0001295	69.26	gold quality
transverse colon	UBERON:0001157	69.16	gold quality
popliteal artery	UBERON:0002250	68.56	gold quality
tibial artery	UBERON:0007610	68.39	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.10	gold quality
right lobe of liver	UBERON:0001114	68.04	gold quality
body of stomach	UBERON:0001161	67.94	gold quality
granulocyte	CL:0000094	67.76	gold quality
heart	UBERON:0000948	67.65	gold quality
left adrenal gland cortex	UBERON:0035825	67.43	gold quality
left adrenal gland	UBERON:0001234	67.30	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.18	gold quality
Ammon’s horn	UBERON:0001954	67.09	gold quality
skin of abdomen	UBERON:0001416	66.11	gold quality
body of uterus	UBERON:0009853	65.96	gold quality
intestine	UBERON:0000160	65.86	gold quality
left coronary artery	UBERON:0001626	65.84	gold quality
colon	UBERON:0001155	65.74	gold quality
lung	UBERON:0002048	65.44	gold quality
hypothalamus	UBERON:0001898	65.40	gold quality
thoracic aorta	UBERON:0001515	65.35	gold quality
skin of leg	UBERON:0001511	65.20	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.48

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.