MIR4696

Summary

MIR4696 (microRNA 4696, HGNC:41780) is a microRNA gene on chromosome 11q13.4.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616402 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41780
Approved symbol	MIR4696
Name	microRNA 4696
Location	11q13.4
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4696
Ensembl gene	ENSG00000265902
Ensembl biotype	miRNA
Entrez	100616402
RNAcentral	URS0000759BDD — ncRNA, 70 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000581431

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000581431 — 1 exons

Exon	Start	End
ENSE00002704535	74720268	74720337

Expression profiles

Bgee: expression breadth broad, 38 present calls, max score 85.30.

Top tissues by expression

38 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
vermiform appendix	UBERON:0001154	85.30	gold quality
endometrium	UBERON:0001295	75.83	gold quality
gastrocnemius	UBERON:0001388	74.41	gold quality
ascending aorta	UBERON:0001496	74.38	gold quality
monocyte	CL:0000576	73.26	gold quality
ectocervix	UBERON:0012249	71.82	gold quality
body of stomach	UBERON:0001161	71.49	gold quality
stomach	UBERON:0000945	71.48	gold quality
smooth muscle tissue	UBERON:0001135	71.29	gold quality
small intestine Peyer’s patch	UBERON:0003454	70.22	gold quality
transverse colon	UBERON:0001157	69.96	gold quality
lower esophagus	UBERON:0013473	69.62	gold quality
myometrium	UBERON:0001296	69.52	gold quality
body of uterus	UBERON:0009853	69.44	gold quality
heart	UBERON:0000948	69.42	gold quality
heart left ventricle	UBERON:0002084	69.41	gold quality
lower esophagus muscularis layer	UBERON:0035833	69.28	gold quality
colon	UBERON:0001155	69.05	gold quality
muscle layer of sigmoid colon	UBERON:0035805	68.93	gold quality
tibial artery	UBERON:0007610	68.80	gold quality
blood	UBERON:0000178	68.74	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.34	gold quality
right atrium auricular region	UBERON:0006631	67.44	gold quality
left uterine tube	UBERON:0001303	66.68	gold quality
fundus of stomach	UBERON:0001160	66.27	gold quality
substantia nigra	UBERON:0002038	66.00	gold quality
esophagus mucosa	UBERON:0002469	64.85	gold quality
caudate nucleus	UBERON:0001873	64.31	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	64.24	gold quality
upper lobe of left lung	UBERON:0008952	63.52	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.66

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.