MIR4697

Summary

MIR4697 (microRNA 4697, HGNC:41570) is a microRNA gene on chromosome 11q25.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616119 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41570
Approved symbol	MIR4697
Name	microRNA 4697
Location	11q25
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4697
Ensembl gene	ENSG00000284020
Ensembl biotype	miRNA
Entrez	100616119
RNAcentral	URS000075C16F — miRNA, 78 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000582977

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000582977 — 1 exons

Exon	Start	End
ENSE00002717536	133898504	133898581

Expression profiles

Bgee: expression breadth broad, 24 present calls, max score 79.65.

Top tissues by expression

24 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lymph node	UBERON:0000029	79.65	gold quality
blood	UBERON:0000178	69.02	gold quality
body of stomach	UBERON:0001161	67.09	gold quality
heart	UBERON:0000948	64.64	gold quality
right atrium auricular region	UBERON:0006631	64.03	gold quality
body of pancreas	UBERON:0001150	63.81	gold quality
gastrocnemius	UBERON:0001388	62.80	gold quality
left adrenal gland	UBERON:0001234	62.33	gold quality
anterior cingulate cortex	UBERON:0009835	61.17	gold quality
heart left ventricle	UBERON:0002084	60.66	gold quality
omental fat pad	UBERON:0010414	60.08	gold quality
left ovary	UBERON:0002119	58.62	gold quality
subcutaneous adipose tissue	UBERON:0002190	57.40	gold quality
transverse colon	UBERON:0001157	57.27	gold quality
left lobe of thyroid gland	UBERON:0001120	56.75	gold quality
right frontal lobe	UBERON:0002810	55.47	gold quality
esophagus mucosa	UBERON:0002469	55.21	gold quality
upper lobe of left lung	UBERON:0008952	54.63	gold quality
spleen	UBERON:0002106	49.98	gold quality
small intestine Peyer’s patch	UBERON:0003454	49.77	gold quality
tibial nerve	UBERON:0001323	48.58	gold quality
skin of leg	UBERON:0001511	48.16	gold quality
vagina	UBERON:0000996	43.42	gold quality
substantia nigra	UBERON:0002038	39.64	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 5)

• suggest that the GCH1 and MIR4697 but not SIPA1L2 and VPS13C are genetic loci influencing risk of Parkinson’s disease in Taiwan (PMID:26804608)
• This study investigated the association of four newly introduced risk loci for PD in an Iranian population and found that rs329648 (MIR4697) is associated with Parkinson’s diseases. (PMID:27653855)
• Our results suggest that rs329648 is associated with risk of developing PD in the Han Chinese population. Our findings should be verified in further studies, and they highlight the need for functional studies of MIR4697. (PMID:28380328)
• Comprehensive network analysis of dysregulated genes revealed MNX1-AS1/hsa-miR-4697-3p/HOXB13 axis in ovarian cancer chemotherapy response. (PMID:35639251)
• Regulation of MicroRNA-4697-3p by Parkinson’s disease-associated SNP rs329648 and its impact on SNCA112 mRNA. (PMID:39001947)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.