MIR4698

Summary

MIR4698 (microRNA 4698, HGNC:41867) is a microRNA gene on chromosome 12q13.11.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616486 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41867
Approved symbol	MIR4698
Name	microRNA 4698
Location	12q13.11
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4698
Ensembl gene	ENSG00000263838
Ensembl biotype	miRNA
Entrez	100616486
RNAcentral	URS000075C516 — miRNA, 80 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000577795

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000577795 — 1 exons

Exon	Start	End
ENSE00002686082	47187812	47187891

Expression profiles

Bgee: expression breadth broad, 65 present calls, max score 80.93.

Top tissues by expression

65 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	80.93	gold quality
adrenal tissue	UBERON:0018303	77.44	gold quality
nucleus accumbens	UBERON:0001882	75.26	gold quality
gastrocnemius	UBERON:0001388	74.48	gold quality
liver	UBERON:0002107	73.28	gold quality
adult mammalian kidney	UBERON:0000082	72.91	gold quality
monocyte	CL:0000576	72.56	gold quality
adrenal gland	UBERON:0002369	70.69	gold quality
stomach	UBERON:0000945	70.11	gold quality
endometrium	UBERON:0001295	69.93	gold quality
left adrenal gland cortex	UBERON:0035825	69.91	gold quality
esophagus mucosa	UBERON:0002469	68.65	gold quality
kidney	UBERON:0002113	68.39	gold quality
body of pancreas	UBERON:0001150	68.30	gold quality
heart	UBERON:0000948	68.16	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.92	gold quality
granulocyte	CL:0000094	67.76	gold quality
right atrium auricular region	UBERON:0006631	67.30	gold quality
heart left ventricle	UBERON:0002084	66.98	gold quality
gall bladder	UBERON:0002110	66.33	gold quality
intestine	UBERON:0000160	66.25	gold quality
muscle layer of sigmoid colon	UBERON:0035805	66.22	gold quality
left coronary artery	UBERON:0001626	66.17	gold quality
colon	UBERON:0001155	66.09	gold quality
tibial artery	UBERON:0007610	66.09	gold quality
lower esophagus muscularis layer	UBERON:0035833	65.93	gold quality
ascending aorta	UBERON:0001496	65.90	gold quality
myometrium	UBERON:0001296	65.63	gold quality
body of stomach	UBERON:0001161	65.24	gold quality
lung	UBERON:0002048	65.19	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.33

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• miR-548x and miR-4698 controlled cell proliferation by affecting the PI3K/AKT signaling pathway in Glioblastoma cell lines. (PMID:32005873)
• miR-4698-Trim59 axis plays a suppressive role in hepatocellular carcinoma. (PMID:32114426)
• lncRNA LIFRAS1 inhibits gastric carcinoma cell proliferation, migration and invasion by sponging miR4698. (PMID:33355363)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.