MIR4699

Summary

MIR4699 (microRNA 4699, HGNC:41636) is a microRNA gene on chromosome 12q21.31.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616133 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41636
Approved symbol	MIR4699
Name	microRNA 4699
Location	12q21.31
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4699
Ensembl gene	ENSG00000265227
Ensembl biotype	miRNA
Entrez	100616133
RNAcentral	URS0000759971 — ncRNA, 74 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000578957

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000578957 — 1 exons

Exon	Start	End
ENSE00002727222	81158388	81158461

Expression profiles

Bgee: expression breadth broad, 39 present calls, max score 81.99.

Top tissues by expression

39 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	81.99	gold quality
calcaneal tendon	UBERON:0003701	80.66	gold quality
lung	UBERON:0002048	74.97	gold quality
monocyte	CL:0000576	73.28	gold quality
gastrocnemius	UBERON:0001388	72.12	gold quality
heart left ventricle	UBERON:0002084	69.89	gold quality
heart	UBERON:0000948	69.85	gold quality
tibial artery	UBERON:0007610	68.16	gold quality
endometrium	UBERON:0001295	67.18	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.97	gold quality
ascending aorta	UBERON:0001496	66.36	gold quality
minor salivary gland	UBERON:0001830	65.81	gold quality
left lobe of thyroid gland	UBERON:0001120	65.66	gold quality
transverse colon	UBERON:0001157	65.26	gold quality
left ovary	UBERON:0002119	64.92	gold quality
omental fat pad	UBERON:0010414	64.86	gold quality
thoracic mammary gland	UBERON:0005200	64.68	gold quality
spleen	UBERON:0002106	64.53	gold quality
subcutaneous adipose tissue	UBERON:0002190	64.22	gold quality
thyroid gland	UBERON:0002046	63.28	gold quality
right ovary	UBERON:0002118	63.03	gold quality
skin of leg	UBERON:0001511	62.80	gold quality
left uterine tube	UBERON:0001303	62.46	gold quality
body of uterus	UBERON:0009853	62.39	gold quality
myometrium	UBERON:0001296	62.26	gold quality
esophagus mucosa	UBERON:0002469	61.91	gold quality
right atrium auricular region	UBERON:0006631	61.89	gold quality
tibial nerve	UBERON:0001323	61.78	gold quality
caudate nucleus	UBERON:0001873	61.76	gold quality
skin of abdomen	UBERON:0001416	61.63	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.30

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.