MIR4701

Summary

MIR4701 (microRNA 4701, HGNC:41627) is a microRNA gene on chromosome 12q13.12.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616262 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41627
Approved symbol	MIR4701
Name	microRNA 4701
Location	12q13.12
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4701
Ensembl gene	ENSG00000264201
Ensembl biotype	miRNA
Entrez	100616262
RNAcentral	URS000075E5C1 — ncRNA, 63 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000583094

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000583094 — 1 exons

Exon	Start	End
ENSE00002712796	48771975	48772037

Expression profiles

Bgee: expression breadth ubiquitous, 111 present calls, max score 93.01.

Top tissues by expression

111 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	93.01	gold quality
descending thoracic aorta	UBERON:0002345	92.10	gold quality
transverse colon	UBERON:0001157	91.78	gold quality
skeletal muscle tissue	UBERON:0001134	91.51	gold quality
ascending aorta	UBERON:0001496	91.49	gold quality
thoracic aorta	UBERON:0001515	91.33	gold quality
vermiform appendix	UBERON:0001154	91.16	gold quality
right coronary artery	UBERON:0001625	91.14	gold quality
rectum	UBERON:0001052	89.89	gold quality
heart left ventricle	UBERON:0002084	89.89	gold quality
duodenum	UBERON:0002114	89.88	gold quality
body of uterus	UBERON:0009853	89.58	gold quality
right atrium auricular region	UBERON:0006631	89.54	gold quality
heart	UBERON:0000948	89.36	gold quality
fundus of stomach	UBERON:0001160	89.16	gold quality
right ovary	UBERON:0002118	89.10	gold quality
body of stomach	UBERON:0001161	88.85	gold quality
left coronary artery	UBERON:0001626	88.67	gold quality
myometrium	UBERON:0001296	88.18	gold quality
tibial artery	UBERON:0007610	88.15	gold quality
popliteal artery	UBERON:0002250	88.12	gold quality
endocervix	UBERON:0000458	88.09	gold quality
mucosa of transverse colon	UBERON:0004991	88.08	gold quality
stomach	UBERON:0000945	87.96	gold quality
thoracic mammary gland	UBERON:0005200	87.82	gold quality
ovary	UBERON:0000992	87.60	gold quality
small intestine	UBERON:0002108	87.48	gold quality
colon	UBERON:0001155	87.40	gold quality
adrenal tissue	UBERON:0018303	87.38	gold quality
intestine	UBERON:0000160	87.37	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• Describe differential expression profiles of alpha-2, 3-sialyltransferases (ST) and miR-4701-5p in three pairs of chronic myeloid leukemia (CML) cell lines and 48 clinical samples of bone marrow mononuclear cells from CML patients. miR-4701-5p directly targeted ST3GAL1 to reduce CML cells resistance to multiple chemotherapeutics in vitro. (PMID:27088512)
• Our results reveal PICSAR may exert an essential role in promoting synovial invasion and joint destruction by sponging miR-4701-5p in RA and that lncRNA PICSAR may act as a biomarker of RA. (PMID:31791845)
• Circular RNA circ_0065378 upregulates tumor suppressor candidate 1 by competitively binding with miR-4701-5p to alleviate colorectal cancer progression. (PMID:35434854)
• microRNA-4701-5p protects against interleukin-1beta induced human chondrocyte CHON-001 cells injury via modulating HMGA1. (PMID:35459188)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.