MIR4705

Summary

MIR4705 (microRNA 4705, HGNC:41567) is a microRNA gene on chromosome 13q33.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616239 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41567
Approved symbol	MIR4705
Name	microRNA 4705
Location	13q33.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4705
Ensembl gene	ENSG00000264482
Ensembl biotype	miRNA
Entrez	100616239
RNAcentral	URS000075B2D7 — ncRNA, 71 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000577547

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000577547 — 1 exons

Exon	Start	End
ENSE00002705001	102045934	102046004

Expression profiles

Bgee: expression breadth broad, 51 present calls, max score 91.90.

Top tissues by expression

51 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
kidney	UBERON:0002113	91.90	gold quality
monocyte	CL:0000576	87.01	gold quality
liver	UBERON:0002107	77.42	gold quality
calcaneal tendon	UBERON:0003701	77.26	gold quality
stomach	UBERON:0000945	74.53	gold quality
corpus callosum	UBERON:0002336	73.17	gold quality
amygdala	UBERON:0001876	72.06	gold quality
tibial artery	UBERON:0007610	69.87	gold quality
heart	UBERON:0000948	67.69	gold quality
blood	UBERON:0000178	66.60	gold quality
omental fat pad	UBERON:0010414	66.16	gold quality
right atrium auricular region	UBERON:0006631	66.05	gold quality
heart left ventricle	UBERON:0002084	65.95	gold quality
intestine	UBERON:0000160	65.49	gold quality
colon	UBERON:0001155	65.48	gold quality
anterior cingulate cortex	UBERON:0009835	65.22	gold quality
Brodmann (1909) area 9	UBERON:0013540	65.20	gold quality
right hemisphere of cerebellum	UBERON:0014890	65.05	gold quality
minor salivary gland	UBERON:0001830	65.04	gold quality
muscle layer of sigmoid colon	UBERON:0035805	64.87	gold quality
skin of leg	UBERON:0001511	64.80	gold quality
skin of abdomen	UBERON:0001416	64.60	gold quality
ascending aorta	UBERON:0001496	64.35	gold quality
left adrenal gland	UBERON:0001234	64.13	gold quality
cerebellar hemisphere	UBERON:0002245	64.02	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	63.98	gold quality
hypothalamus	UBERON:0001898	63.76	gold quality
Ammon’s horn	UBERON:0001954	63.69	gold quality
transverse colon	UBERON:0001157	63.66	gold quality
small intestine Peyer’s patch	UBERON:0003454	63.47	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.21

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.