MIR4707

Summary

MIR4707 (microRNA 4707, HGNC:41531) is a microRNA gene on chromosome 14q11.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616424 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41531
Approved symbol	MIR4707
Name	microRNA 4707
Location	14q11.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4707
Ensembl gene	ENSG00000284118
Ensembl biotype	miRNA
Entrez	100616424
RNAcentral	URS000075ED9B — ncRNA, 80 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000579686

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000579686 — 1 exons

Exon	Start	End
ENSE00002712197	22956950	22957029

Expression profiles

Bgee: expression breadth tissue_specific, 5 present calls, max score 69.94.

FANTOM5 (CAGE): breadth broad, TPM avg 0.6094 / max 10.7005, expressed in 367 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
142269	0.6094	367

Top tissues by expression

19 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow	UBERON:0002371	69.94	silver quality
subcutaneous adipose tissue	UBERON:0002190	69.73	silver quality
skeletal muscle tissue	UBERON:0001134	68.75	silver quality
liver	UBERON:0002107	68.62	silver quality
endometrium	UBERON:0001295	67.76	gold quality
kidney	UBERON:0002113	67.36	silver quality
thymus	UBERON:0002370	67.13	silver quality
spinal cord	UBERON:0002240	67.11	gold quality
lung	UBERON:0002048	66.55	silver quality
pancreas	UBERON:0001264	65.67	silver quality
spleen	UBERON:0002106	65.28	silver quality
quadriceps femoris	UBERON:0001377	61.63	gold quality
heart	UBERON:0000948	60.72	silver quality
prostate gland	UBERON:0002367	60.44	gold quality
brain	UBERON:0000955	58.72	gold quality
frontal cortex	UBERON:0001870	58.61	gold quality
caudate nucleus	UBERON:0001873	58.53	gold quality
cerebellar vermis	UBERON:0004720	58.50	gold quality
anterior cingulate cortex	UBERON:0009835	54.03	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Study provides evidence that Long Noncoding RNA LOC100129973 suppresses apoptosis by targeting miR-4707-5p and miR-4767 in vascular endothelial cells. (PMID:26887505)
• MicroRNA-eQTLs in the developing human neocortex link miR-4707-3p expression to brain size. (PMID:36629315)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.