MIR4708

Summary

MIR4708 (microRNA 4708, HGNC:41824) is a microRNA gene on chromosome 14q23.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616176 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41824
Approved symbol	MIR4708
Name	microRNA 4708
Location	14q23.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4708
Ensembl gene	ENSG00000266740
Ensembl biotype	miRNA
Entrez	100616176
RNAcentral	URS000075C230 — ncRNA, 67 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000584635

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000584635 — 1 exons

Exon	Start	End
ENSE00002692335	65335117	65335183

Expression profiles

Bgee: expression breadth tissue_specific, 5 present calls, max score 80.32.

Top tissues by expression

5 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	80.32	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	65.82	gold quality
upper lobe of left lung	UBERON:0008952	63.47	gold quality
corpus callosum	UBERON:0002336	44.18	silver quality
left testis	UBERON:0004533	41.99	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.65

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.