MIR4710

gene

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Also known as hsa-mir-4710

Summary

MIR4710 (microRNA 4710, HGNC:41727) is a microRNA gene on chromosome 14q32.33.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616300 — RefSeq curated summary.

At a glance

Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41727
Approved symbol	MIR4710
Name	microRNA 4710
Location	14q32.33
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4710
Ensembl gene	ENSG00000265291
Ensembl biotype	miRNA
Entrez	100616300
RNAcentral	URS000075BC3B — ncRNA, 56 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000582316

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000582316 — 1 exons

Exon	Start	End
ENSE00002729592	104677694	104677749

Expression profiles

Bgee: expression breadth broad, 49 present calls, max score 79.20.

Top tissues by expression

49 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	79.20	gold quality
blood	UBERON:0000178	75.71	gold quality
gastrocnemius	UBERON:0001388	75.51	gold quality
heart left ventricle	UBERON:0002084	73.02	gold quality
left ovary	UBERON:0002119	72.50	gold quality
endometrium	UBERON:0001295	71.81	gold quality
fundus of stomach	UBERON:0001160	71.39	gold quality
hypothalamus	UBERON:0001898	70.92	gold quality
right atrium auricular region	UBERON:0006631	70.70	gold quality
ascending aorta	UBERON:0001496	69.95	gold quality
thoracic aorta	UBERON:0001515	69.89	gold quality
left adrenal gland	UBERON:0001234	69.46	gold quality
putamen	UBERON:0001874	69.18	gold quality
stomach	UBERON:0000945	68.87	gold quality
body of stomach	UBERON:0001161	68.78	gold quality
omental fat pad	UBERON:0010414	68.67	gold quality
tibial artery	UBERON:0007610	68.37	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.97	gold quality
esophagus mucosa	UBERON:0002469	67.91	gold quality
subcutaneous adipose tissue	UBERON:0002190	67.27	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	67.26	gold quality
Brodmann (1909) area 9	UBERON:0013540	67.04	gold quality
transverse colon	UBERON:0001157	67.02	gold quality
urinary bladder	UBERON:0001255	66.76	gold quality
Ammon’s horn	UBERON:0001954	66.42	gold quality
skin of abdomen	UBERON:0001416	66.29	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.16	gold quality
skin of leg	UBERON:0001511	66.05	gold quality
small intestine Peyer’s patch	UBERON:0003454	66.04	gold quality
thoracic mammary gland	UBERON:0005200	66.01	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.30

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

Downregulated miR-367-3p, miR-548aq-5p, and miR-4710 in Human Whole Blood: Potential Biomarkers for Breast Cancer With Axillary Lymph Node Metastasis. (PMID:36564279)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.

Disease cohort memberships (association, not causation — diseases whose associated-gene cohort lists this gene; a subset are also under Associated diseases): small cell lung carcinoma