MIR4711

Summary

MIR4711 (microRNA 4711, HGNC:41847) is a microRNA gene on chromosome 1p32.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616409 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41847
Approved symbol	MIR4711
Name	microRNA 4711
Location	1p32.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4711
Ensembl gene	ENSG00000266150
Ensembl biotype	miRNA
Entrez	100616409
RNAcentral	URS000075E6AD — miRNA, 70 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000578274

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000578274 — 1 exons

Exon	Start	End
ENSE00002696101	59733227	59733296

Expression profiles

Bgee: expression breadth broad, 57 present calls, max score 82.25.

Top tissues by expression

57 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	82.25	gold quality
adrenal tissue	UBERON:0018303	77.67	gold quality
liver	UBERON:0002107	76.30	gold quality
blood	UBERON:0000178	75.42	gold quality
muscle of leg	UBERON:0001383	73.83	gold quality
gastrocnemius	UBERON:0001388	73.20	gold quality
islet of Langerhans	UBERON:0000006	72.45	gold quality
monocyte	CL:0000576	71.79	gold quality
kidney	UBERON:0002113	70.59	gold quality
heart	UBERON:0000948	70.40	gold quality
right lobe of liver	UBERON:0001114	69.92	gold quality
tibial artery	UBERON:0007610	69.65	gold quality
ascending aorta	UBERON:0001496	69.29	gold quality
adult mammalian kidney	UBERON:0000082	69.13	gold quality
body of stomach	UBERON:0001161	68.81	gold quality
muscle layer of sigmoid colon	UBERON:0035805	68.73	gold quality
transverse colon	UBERON:0001157	68.28	gold quality
esophagus mucosa	UBERON:0002469	68.27	gold quality
nucleus accumbens	UBERON:0001882	68.19	gold quality
small intestine Peyer’s patch	UBERON:0003454	67.32	gold quality
body of pancreas	UBERON:0001150	67.19	gold quality
right atrium auricular region	UBERON:0006631	66.93	gold quality
right adrenal gland	UBERON:0001233	66.88	gold quality
left adrenal gland	UBERON:0001234	66.24	gold quality
subcutaneous adipose tissue	UBERON:0002190	66.22	gold quality
colon	UBERON:0001155	66.07	gold quality
right adrenal gland cortex	UBERON:0035827	65.96	gold quality
left coronary artery	UBERON:0001626	65.74	gold quality
skin of leg	UBERON:0001511	65.47	gold quality
left adrenal gland cortex	UBERON:0035825	64.93	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.49

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• miR-4711-5p regulates cancer stemness and cell cycle progression via KLF5, MDM2 and TFDP1 in colon cancer cells. (PMID:32066912)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.