MIR4712

Summary

MIR4712 (microRNA 4712, HGNC:41732) is a microRNA gene on chromosome 15q21.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616396 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41732
Approved symbol	MIR4712
Name	microRNA 4712
Location	15q21.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4712
Ensembl gene	ENSG00000284284
Ensembl biotype	miRNA
Entrez	100616396
RNAcentral	URS000075E004 — ncRNA, 82 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000583750

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000583750 — 1 exons

Exon	Start	End
ENSE00002718381	50360329	50360410

Expression profiles

Bgee: expression breadth broad, 26 present calls, max score 76.21.

Top tissues by expression

26 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
nucleus accumbens	UBERON:0001882	76.21	gold quality
bone marrow	UBERON:0002371	76.15	gold quality
gastrocnemius	UBERON:0001388	71.38	gold quality
blood	UBERON:0000178	69.46	gold quality
liver	UBERON:0002107	66.31	gold quality
subcutaneous adipose tissue	UBERON:0002190	64.39	gold quality
lower esophagus muscularis layer	UBERON:0035833	63.42	gold quality
body of stomach	UBERON:0001161	62.19	gold quality
body of pancreas	UBERON:0001150	61.69	gold quality
islet of Langerhans	UBERON:0000006	61.63	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	61.30	gold quality
heart left ventricle	UBERON:0002084	60.48	gold quality
tibial artery	UBERON:0007610	60.25	gold quality
ascending aorta	UBERON:0001496	59.26	gold quality
right atrium auricular region	UBERON:0006631	54.37	gold quality
omental fat pad	UBERON:0010414	54.28	gold quality
left adrenal gland	UBERON:0001234	53.63	gold quality
spleen	UBERON:0002106	51.03	gold quality
skin of leg	UBERON:0001511	50.41	gold quality
putamen	UBERON:0001874	49.77	gold quality
esophagus mucosa	UBERON:0002469	49.48	gold quality
left adrenal gland cortex	UBERON:0035825	48.97	gold quality
hypothalamus	UBERON:0001898	46.72	gold quality
upper lobe of left lung	UBERON:0008952	43.71	gold quality
substantia nigra	UBERON:0002038	42.80	gold quality
right hemisphere of cerebellum	UBERON:0014890	42.78	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Results demonstrated that the expression of miR4712 in vulvar squamous cell carcinoma (VSCC) was significant high. microRNA4712 can reduce the expression of PTEN, further affecting its downstream pAKT, pGSK3beta and cyclin D1 signaling pathways, promoting the proliferation and invasion of VSCC. (PMID:31545465)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.