MIR4714

Summary

MIR4714 (microRNA 4714, HGNC:41763) is a microRNA gene on chromosome 15q26.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616432 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41763
Approved symbol	MIR4714
Name	microRNA 4714
Location	15q26.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4714
Ensembl gene	ENSG00000264480
Ensembl biotype	miRNA
Entrez	100616432
RNAcentral	URS000075E72D — miRNA, 77 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000580728

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000580728 — 1 exons

Exon	Start	End
ENSE00002700565	98784426	98784502

Expression profiles

Bgee: expression breadth broad, 70 present calls, max score 96.28.

Top tissues by expression

70 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	96.28	gold quality
blood	UBERON:0000178	82.53	gold quality
calcaneal tendon	UBERON:0003701	82.16	gold quality
kidney	UBERON:0002113	79.55	gold quality
lung	UBERON:0002048	78.92	gold quality
monocyte	CL:0000576	77.35	gold quality
stomach	UBERON:0000945	76.79	gold quality
endometrium	UBERON:0001295	75.67	gold quality
fundus of stomach	UBERON:0001160	74.04	gold quality
heart	UBERON:0000948	73.89	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	70.26	gold quality
gastrocnemius	UBERON:0001388	70.13	gold quality
right frontal lobe	UBERON:0002810	69.37	gold quality
right atrium auricular region	UBERON:0006631	69.23	gold quality
adult mammalian kidney	UBERON:0000082	68.91	gold quality
intestine	UBERON:0000160	68.80	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.27	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	67.91	gold quality
body of stomach	UBERON:0001161	67.36	gold quality
substantia nigra	UBERON:0002038	67.01	gold quality
body of pancreas	UBERON:0001150	66.69	gold quality
popliteal artery	UBERON:0002250	66.52	gold quality
liver	UBERON:0002107	66.34	gold quality
tibial artery	UBERON:0007610	66.19	gold quality
skin of abdomen	UBERON:0001416	66.17	gold quality
ascending aorta	UBERON:0001496	65.99	gold quality
lower esophagus muscularis layer	UBERON:0035833	65.81	gold quality
ectocervix	UBERON:0012249	65.63	gold quality
zone of skin	UBERON:0000014	65.61	gold quality
colon	UBERON:0001155	65.60	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.81

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.