MIR4715

Summary

MIR4715 (microRNA 4715, HGNC:41666) is a microRNA gene on chromosome 15q12.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616474 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41666
Approved symbol	MIR4715
Name	microRNA 4715
Location	15q12
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4715
Ensembl gene	ENSG00000266517
Ensembl biotype	miRNA
Entrez	100616474
RNAcentral	URS000075E8CB — ncRNA, 79 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000584117

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000584117 — 1 exons

Exon	Start	End
ENSE00002711281	25848747	25848825

Expression profiles

Bgee: expression breadth broad, 63 present calls, max score 82.11.

Top tissues by expression

63 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	82.11	gold quality
monocyte	CL:0000576	76.93	gold quality
blood	UBERON:0000178	76.48	gold quality
calcaneal tendon	UBERON:0003701	74.77	gold quality
right atrium auricular region	UBERON:0006631	74.75	gold quality
muscle of leg	UBERON:0001383	74.74	gold quality
lymph node	UBERON:0000029	72.57	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	70.82	gold quality
gastrocnemius	UBERON:0001388	70.28	gold quality
kidney	UBERON:0002113	69.65	gold quality
tibial artery	UBERON:0007610	68.58	gold quality
popliteal artery	UBERON:0002250	68.46	gold quality
left ovary	UBERON:0002119	68.01	gold quality
body of stomach	UBERON:0001161	68.00	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.19	gold quality
ascending aorta	UBERON:0001496	67.15	gold quality
left coronary artery	UBERON:0001626	67.15	gold quality
thoracic aorta	UBERON:0001515	67.05	gold quality
heart left ventricle	UBERON:0002084	66.97	gold quality
esophagus mucosa	UBERON:0002469	66.72	gold quality
Ammon’s horn	UBERON:0001954	66.64	gold quality
Brodmann (1909) area 9	UBERON:0013540	66.46	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	65.88	gold quality
skin of abdomen	UBERON:0001416	65.86	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	65.77	gold quality
right frontal lobe	UBERON:0002810	65.71	gold quality
adult mammalian kidney	UBERON:0000082	65.32	gold quality
amygdala	UBERON:0001876	65.25	gold quality
liver	UBERON:0002107	65.23	silver quality
myometrium	UBERON:0001296	65.20	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.48

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• Epigenetic regulation of AURKA by miR-4715-3p in upper gastrointestinal cancers. (PMID:31740746)
• ur study identified a novel lncRNA associated with poor prognosis in lung cancer. LCAT1 is an oncogenic regulator that promotes cell proliferation and metastasis (PMID:31779616)
• The macrophage-associated microRNA-4715-3p / Gasdermin D axis potentially indicates fibrosis progression in nonalcoholic fatty liver disease: evidence from transcriptome and biological data. (PMID:35521691)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.