MIR4716

Summary

MIR4716 (microRNA 4716, HGNC:41812) is a microRNA gene on chromosome 15q21.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616332 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41812
Approved symbol	MIR4716
Name	microRNA 4716
Location	15q21.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4716
Ensembl gene	ENSG00000264210
Ensembl biotype	miRNA
Entrez	100616332
RNAcentral	URS000075BB93 — miRNA, 84 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000579628

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000579628 — 1 exons

Exon	Start	End
ENSE00002705372	49169070	49169153

Expression profiles

Bgee: expression breadth broad, 54 present calls, max score 80.81.

Top tissues by expression

54 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	80.81	gold quality
blood	UBERON:0000178	77.52	gold quality
kidney	UBERON:0002113	76.62	gold quality
endometrium	UBERON:0001295	73.13	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	72.73	gold quality
body of pancreas	UBERON:0001150	71.80	gold quality
adult mammalian kidney	UBERON:0000082	71.09	gold quality
stomach	UBERON:0000945	70.96	gold quality
heart	UBERON:0000948	70.64	gold quality
Ammon’s horn	UBERON:0001954	70.40	gold quality
gastrocnemius	UBERON:0001388	69.73	gold quality
left coronary artery	UBERON:0001626	68.85	gold quality
Brodmann (1909) area 9	UBERON:0013540	68.23	gold quality
lung	UBERON:0002048	67.84	gold quality
tibial artery	UBERON:0007610	67.43	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.30	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.26	gold quality
intestine	UBERON:0000160	66.21	gold quality
right lobe of liver	UBERON:0001114	66.16	gold quality
omental fat pad	UBERON:0010414	65.97	gold quality
vagina	UBERON:0000996	65.93	gold quality
anterior cingulate cortex	UBERON:0009835	65.75	gold quality
putamen	UBERON:0001874	65.61	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	65.24	gold quality
body of stomach	UBERON:0001161	64.87	gold quality
right adrenal gland cortex	UBERON:0035827	64.85	gold quality
esophagus mucosa	UBERON:0002469	64.39	gold quality
substantia nigra	UBERON:0002038	63.97	gold quality
small intestine Peyer’s patch	UBERON:0003454	63.94	gold quality
transverse colon	UBERON:0001157	63.77	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.49

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.