MIR4717

Summary

MIR4717 (microRNA 4717, HGNC:41571) is a microRNA gene on chromosome 16p13.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616241 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41571
Approved symbol	MIR4717
Name	microRNA 4717
Location	16p13.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4717
Ensembl gene	ENSG00000264004
Ensembl biotype	miRNA
Entrez	100616241
RNAcentral	URS000075EC4C — miRNA, 72 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000584656

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000584656 — 1 exons

Exon	Start	End
ENSE00002687477	2274620	2274691

Expression profiles

Bgee: expression breadth broad, 20 present calls, max score 75.00.

Top tissues by expression

20 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
gastrocnemius	UBERON:0001388	75.00	gold quality
tibial artery	UBERON:0007610	71.14	gold quality
amygdala	UBERON:0001876	70.60	gold quality
nucleus accumbens	UBERON:0001882	68.60	gold quality
ascending aorta	UBERON:0001496	65.68	gold quality
upper lobe of left lung	UBERON:0008952	65.01	gold quality
caudate nucleus	UBERON:0001873	64.83	gold quality
subcutaneous adipose tissue	UBERON:0002190	64.65	gold quality
ectocervix	UBERON:0012249	64.11	gold quality
lower esophagus muscularis layer	UBERON:0035833	63.91	gold quality
muscle layer of sigmoid colon	UBERON:0035805	63.69	gold quality
cerebellar hemisphere	UBERON:0002245	63.42	gold quality
vagina	UBERON:0000996	62.55	gold quality
right frontal lobe	UBERON:0002810	61.87	gold quality
anterior cingulate cortex	UBERON:0009835	61.56	gold quality
Brodmann (1909) area 9	UBERON:0013540	61.39	gold quality
left adrenal gland cortex	UBERON:0035825	59.58	gold quality
pituitary gland	UBERON:0000007	57.38	gold quality
thyroid gland	UBERON:0002046	51.36	gold quality
corpus callosum	UBERON:0002336	43.61	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.66

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 6)

• MIR4717 regulates human RGS2 and contributes to the genetic risk towards anxiety-related traits. (PMID:25847876)
• MiR-4717 may allele-specifically regulate PD-1 expression through interaction with the 3’ UTR of PD1 mRNA, leading to the alteration of immune regulation and affecting the susceptibility and disease course of chronic HBV infection. (PMID:25895129)
• This study using microarray technology found two miRNAs including has-miR-4717-5p and has-miR-642b-5p were upregulated in patients with Guillain-Barre syndrome. (PMID:27836180)
• High miR4717 expression is associated with colorectal cancer tissues infected with Fusobacterium nucleatum. (PMID:30951563)
• Exosomes secreted from cancer-associated fibroblasts elicit anti-pyrimidine drug resistance through modulation of its transporter in malignant lymphoma. (PMID:33994542)
• Fusobacterium nucleatum induces excess methyltransferase-like 3-mediated microRNA-4717-3p maturation to promote colorectal cancer cell proliferation. (PMID:35984699)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.