MIR4718

Summary

MIR4718 (microRNA 4718, HGNC:41900) is a microRNA gene on chromosome 16p13.12.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616195 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41900
Approved symbol	MIR4718
Name	microRNA 4718
Location	16p13.12
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4718
Ensembl gene	ENSG00000264733
Ensembl biotype	miRNA
Entrez	100616195
RNAcentral	URS000075A6BF — ncRNA, 51 nt, 6 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000580978

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000580978 — 1 exons

Exon	Start	End
ENSE00002710419	12720321	12720371

Expression profiles

Bgee: expression breadth broad, 51 present calls, max score 98.84.

Top tissues by expression

51 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	98.84	gold quality
blood	UBERON:0000178	85.14	gold quality
lung	UBERON:0002048	80.62	gold quality
heart	UBERON:0000948	78.44	gold quality
gastrocnemius	UBERON:0001388	78.42	gold quality
monocyte	CL:0000576	75.86	gold quality
stomach	UBERON:0000945	75.74	gold quality
kidney	UBERON:0002113	75.50	gold quality
adrenal tissue	UBERON:0018303	75.17	gold quality
putamen	UBERON:0001874	74.95	gold quality
adult mammalian kidney	UBERON:0000082	74.64	gold quality
liver	UBERON:0002107	74.62	gold quality
tibial nerve	UBERON:0001323	74.16	gold quality
calcaneal tendon	UBERON:0003701	74.02	gold quality
islet of Langerhans	UBERON:0000006	73.07	gold quality
heart left ventricle	UBERON:0002084	71.73	gold quality
right lobe of liver	UBERON:0001114	71.18	gold quality
right hemisphere of cerebellum	UBERON:0014890	69.99	gold quality
tibial artery	UBERON:0007610	69.80	gold quality
lower esophagus mucosa	UBERON:0035834	69.34	gold quality
prostate gland	UBERON:0002367	69.31	gold quality
omental fat pad	UBERON:0010414	69.20	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	68.95	gold quality
esophagus mucosa	UBERON:0002469	68.90	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.80	gold quality
intestine	UBERON:0000160	68.66	gold quality
upper lobe of left lung	UBERON:0008952	68.60	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.13	gold quality
mucosa of transverse colon	UBERON:0004991	67.67	gold quality
skin of leg	UBERON:0001511	67.41	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.21

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• MiR-3168, miR-6125, and miR-4718 as potential predictors of cisplatin-induced nephrotoxicity in patients with head and neck cancer. (PMID:34011306)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.