MIR4719

Summary

MIR4719 (microRNA 4719, HGNC:41807) is a microRNA gene on chromosome 16q23.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616172 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41807
Approved symbol	MIR4719
Name	microRNA 4719
Location	16q23.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4719
Ensembl gene	ENSG00000266426
Ensembl biotype	miRNA
Entrez	100616172
RNAcentral	URS000075E2D2 — miRNA, 84 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000585233

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000585233 — 1 exons

Exon	Start	End
ENSE00002685862	76868936	76869019

Expression profiles

Bgee: expression breadth broad, 16 present calls, max score 81.17.

Top tissues by expression

16 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
intestine	UBERON:0000160	81.17	gold quality
stomach	UBERON:0000945	80.99	gold quality
blood	UBERON:0000178	76.44	gold quality
heart	UBERON:0000948	75.93	gold quality
hypothalamus	UBERON:0001898	73.62	gold quality
monocyte	CL:0000576	73.19	gold quality
amygdala	UBERON:0001876	68.25	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.55	gold quality
Brodmann (1909) area 9	UBERON:0013540	65.27	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	64.45	gold quality
right frontal lobe	UBERON:0002810	63.91	gold quality
anterior cingulate cortex	UBERON:0009835	63.05	gold quality
subcutaneous adipose tissue	UBERON:0002190	62.71	gold quality
right lobe of thyroid gland	UBERON:0001119	61.36	gold quality
corpus callosum	UBERON:0002336	50.23	gold quality
left testis	UBERON:0004533	49.29	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.16

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.