MIR4720

Summary

MIR4720 (microRNA 4720, HGNC:41705) is a microRNA gene on chromosome 16q23.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616150 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41705
Approved symbol	MIR4720
Name	microRNA 4720
Location	16q23.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4720
Ensembl gene	ENSG00000284473
Ensembl biotype	miRNA
Entrez	100616150
RNAcentral	URS000075B68E — ncRNA, 76 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000581455

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000581455 — 1 exons

Exon	Start	End
ENSE00002723385	81385018	81385093

Expression profiles

Bgee: expression breadth broad, 12 present calls, max score 71.46.

Top tissues by expression

12 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	71.46	gold quality
gastrocnemius	UBERON:0001388	66.91	gold quality
adult mammalian kidney	UBERON:0000082	66.50	gold quality
endometrium	UBERON:0001295	64.04	gold quality
tibial artery	UBERON:0007610	62.34	gold quality
ascending aorta	UBERON:0001496	60.71	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	60.27	gold quality
subcutaneous adipose tissue	UBERON:0002190	55.23	gold quality
tibial nerve	UBERON:0001323	50.61	gold quality
prostate gland	UBERON:0002367	47.23	gold quality
left lobe of thyroid gland	UBERON:0001120	46.64	gold quality
omental fat pad	UBERON:0010414	46.58	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.