MIR4721

Summary

MIR4721 (microRNA 4721, HGNC:41609) is a microRNA gene on chromosome 16p11.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616256 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41609
Approved symbol	MIR4721
Name	microRNA 4721
Location	16p11.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4721
Ensembl gene	ENSG00000283845
Ensembl biotype	miRNA
Entrez	100616256
RNAcentral	URS000075EF66 — miRNA, 89 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000577590

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000577590 — 1 exons

Exon	Start	End
ENSE00002693674	28843919	28844007

Expression profiles

Bgee: expression breadth broad, 69 present calls, max score 76.15.

Top tissues by expression

69 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	76.15	gold quality
gastrocnemius	UBERON:0001388	73.47	gold quality
monocyte	CL:0000576	72.20	gold quality
lower esophagus mucosa	UBERON:0035834	71.93	gold quality
stomach	UBERON:0000945	70.85	gold quality
body of stomach	UBERON:0001161	70.27	gold quality
Ammon’s horn	UBERON:0001954	70.04	gold quality
heart left ventricle	UBERON:0002084	69.84	gold quality
adrenal gland	UBERON:0002369	69.62	gold quality
right atrium auricular region	UBERON:0006631	69.52	gold quality
left adrenal gland	UBERON:0001234	69.30	gold quality
body of pancreas	UBERON:0001150	68.95	gold quality
body of uterus	UBERON:0009853	68.76	gold quality
left adrenal gland cortex	UBERON:0035825	68.65	gold quality
endometrium	UBERON:0001295	68.41	gold quality
granulocyte	CL:0000094	68.02	gold quality
right lobe of liver	UBERON:0001114	67.92	gold quality
amygdala	UBERON:0001876	67.53	gold quality
tibial artery	UBERON:0007610	67.53	gold quality
ascending aorta	UBERON:0001496	67.51	gold quality
right adrenal gland cortex	UBERON:0035827	67.48	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.08	gold quality
descending thoracic aorta	UBERON:0002345	67.00	gold quality
omental fat pad	UBERON:0010414	66.91	gold quality
liver	UBERON:0002107	66.67	gold quality
Brodmann (1909) area 9	UBERON:0013540	66.60	gold quality
substantia nigra	UBERON:0002038	66.57	gold quality
anterior cingulate cortex	UBERON:0009835	66.50	gold quality
myometrium	UBERON:0001296	66.49	gold quality
transverse colon	UBERON:0001157	66.46	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.12

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• A direct negative feedback loop of miR-4721/FOXA1/Nanog promotes nasopharyngeal cell stem cell enrichment and metastasis. (PMID:34503528)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.